Detailed information of TA system TA065912

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1607002..1607581
• Replicon: chromosome
• Accession: NZ_CP017090
• Organism: Staphylococcus aureus strain ISU935 isolate ST5

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: A2V17_RS08080
• Protein ID: WP_001025401.1
• Coordinates: 1607336..1607581 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1607002..1607367 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2V17_RS08040	1603745..1604302	-	558	WP_000645049.1	DUF2815 family protein	-
A2V17_RS08045	1604328..1605494	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
A2V17_RS08050	1605491..1605853	-	363	WP_000985976.1	hypothetical protein	-
A2V17_RS08055	1605868..1606191	-	324	WP_000174994.1	hypothetical protein	-
A2V17_RS08060	1606270..1606431	-	162	WP_001285963.1	DUF1270 family protein	-
A2V17_RS08065	1606444..1606707	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
A2V17_RS08070	1606732..1606947	-	216	WP_001036302.1	hypothetical protein	-
A2V17_RS08075	1607002..1607367	+	366	WP_001128433.1	hypothetical protein	Antitoxin
A2V17_RS08080	1607336..1607581	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
A2V17_RS08085	1607637..1607846	+	210	WP_000642492.1	hypothetical protein	-
A2V17_RS08090	1607836..1607979	-	144	WP_000939498.1	hypothetical protein	-
A2V17_RS08095	1608067..1608258	-	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
A2V17_RS08100	1608419..1608748	+	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
A2V17_RS08105	1608761..1609222	+	462	WP_088401709.1	toxin	-
A2V17_RS08110	1609240..1609674	+	435	WP_000755721.1	hypothetical protein	-
A2V17_RS08115	1609703..1610098	+	396	WP_000449657.1	hypothetical protein	-
A2V17_RS08120	1610188..1610334	+	147	WP_001795334.1	hypothetical protein	-
A2V17_RS08125	1610331..1610945	-	615	WP_031808062.1	hypothetical protein	-
A2V17_RS08130	1611071..1612276	+	1206	WP_088401710.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1563466..1629902	66436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T65912 WP_001025401.1 NZ_CP017090:c1607581-1607336 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T65912 NZ_CP017090:c1607581-1607336 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT65912 NZ_CP017090:1607002-1607367 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin