Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1879253..1879772 Replicon chromosome
Accession NZ_CP017088
Organism Streptococcus suis strain SRD478

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3Q8BD70
Locus tag A7J08_RS09355 Protein ID WP_053867320.1
Coordinates 1879253..1879510 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag A7J08_RS09360 Protein ID WP_029693536.1
Coordinates 1879512..1879772 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7J08_RS09345 1876173..1877903 - 1731 WP_053867081.1 hypothetical protein -
A7J08_RS09350 1878266..1879138 - 873 WP_148115852.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
A7J08_RS09355 1879253..1879510 - 258 WP_053867320.1 Txe/YoeB family addiction module toxin Toxin
A7J08_RS09360 1879512..1879772 - 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7J08_RS09365 1880451..1880906 - 456 WP_053867322.1 8-oxo-dGTP diphosphatase -
A7J08_RS09370 1880911..1881279 - 369 WP_053867321.1 hypothetical protein -
A7J08_RS09375 1881272..1881862 - 591 WP_053867450.1 ribonuclease M5 -
A7J08_RS09380 1881825..1882607 - 783 WP_002939015.1 TatD family hydrolase -
A7J08_RS09385 1882715..1882852 - 138 WP_002939016.1 50S ribosomal protein L34 -
A7J08_RS09390 1883020..1884015 - 996 WP_013730624.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1868407..1882607 14200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10305.80 Da        Isoelectric Point: 7.2738

>T65910 WP_053867320.1 NZ_CP017088:c1879510-1879253 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGTWSRRIDAENRLIYMVEAERLCILSL
KDHYG

Download         Length: 258 bp

>T65910 NZ_CP017088:c1879510-1879253 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCTTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAAATTATCAAGGATATGCAACGACACCCGTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTACCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTGGAGGCTGAACGGTTGTGCATCCTGTCGCTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT65910 WP_029693536.1 NZ_CP017088:c1879772-1879512 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT65910 NZ_CP017088:c1879772-1879512 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAACCACTTAAAGGACTATATGAAAAAGGTCAATGATGAGTTTGAGCCCTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTTG
CTGTTGCTCGGAACACTTATCTGTCCCAAAAAGTTCTACGTGGTATGGCTCAAGTCAAAGCGGGACAAACTCAAGAACGA
AACCTGATAGAGGCGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8BD70

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References