Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4095101..4095801 Replicon chromosome
Accession NZ_CP017073
Organism Pseudomonas putida strain PP112420

Toxin (Protein)


Gene name mqsR Uniprot ID B0KNY8
Locus tag BG030_RS18700 Protein ID WP_012273366.1
Coordinates 4095505..4095801 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID B0KNY7
Locus tag BG030_RS18695 Protein ID WP_012273365.1
Coordinates 4095101..4095502 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG030_RS18675 4090238..4091059 - 822 WP_060514479.1 transporter substrate-binding domain-containing protein -
BG030_RS18680 4091136..4092065 - 930 WP_060493838.1 FAD-binding protein -
BG030_RS18685 4092066..4092815 - 750 WP_012273363.1 electron transfer flavoprotein subunit beta/FixA family protein -
BG030_RS18690 4093348..4095030 + 1683 WP_071984592.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
BG030_RS18695 4095101..4095502 - 402 WP_012273365.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BG030_RS18700 4095505..4095801 - 297 WP_012273366.1 type II toxin-antitoxin system MqsR family toxin Toxin
BG030_RS18705 4095896..4097221 - 1326 WP_012273367.1 MFS transporter -
BG030_RS18710 4097294..4097773 - 480 WP_012273368.1 response regulator -
BG030_RS18715 4097943..4098419 - 477 WP_012273369.1 sigma-70 family RNA polymerase sigma factor -
BG030_RS18720 4098657..4099829 + 1173 WP_041166759.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11239.13 Da        Isoelectric Point: 9.4791

>T65865 WP_012273366.1 NZ_CP017073:c4095801-4095505 [Pseudomonas putida]
MEKRTPHCPLERIRALLSAGRVNPTTASLRGAQALGMEFADMLQVIAGLERRDFYKSMSCYVNHRVWQDVYRPFTAKGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

>T65865 NZ_CP017073:c4095801-4095505 [Pseudomonas putida]
ATGGAAAAGAGAACGCCTCATTGTCCGCTGGAGCGGATCAGGGCATTGCTGAGCGCTGGCCGCGTCAACCCTACAACGGC
CTCATTACGAGGCGCTCAGGCGTTAGGGATGGAGTTTGCGGACATGCTTCAGGTTATCGCGGGCCTGGAGCGCAGGGACT
TCTACAAAAGCATGTCTTGTTATGTCAATCATCGCGTTTGGCAAGATGTCTACAGGCCGTTTACGGCGAAAGGCTACGTG
TACCTGAAGCTGTCTGTGGTTGATGACGTTCTCATCGTGTCTTTCAAGGAGTTGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14551.58 Da        Isoelectric Point: 4.7589

>AT65865 WP_012273365.1 NZ_CP017073:c4095502-4095101 [Pseudomonas putida]
MRCPICGGAELAPDTQDMPYRYKGVSTVIPGVAGDYCSACGEAVLGYDEAMRVSDLMSAFSRQVNAKDVDPDFIVSVRKK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT65865 NZ_CP017073:c4095502-4095101 [Pseudomonas putida]
ATGAGATGCCCAATTTGCGGCGGTGCGGAGCTCGCGCCAGACACTCAGGACATGCCCTACCGCTACAAGGGGGTATCGAC
AGTGATCCCTGGTGTCGCGGGCGATTACTGCTCTGCCTGTGGTGAGGCAGTACTTGGCTACGATGAGGCTATGCGCGTCA
GCGATCTGATGTCTGCTTTCAGCCGCCAAGTCAATGCTAAGGATGTCGACCCTGATTTTATTGTTTCCGTGCGCAAGAAG
TTTGATCTGGACCAGCGTGAAGCGGGGGAAATCTTCGGTGGAGGGGTCAATGCGTTCTCTCGATATGAAAACGGCAAGAC
CACGCCACCCGTGGCGCTGGTGAAACTGCTGAAACTGCTGGATCGCCACCCAGAGCTTTTCGAGGAAGTACGTACAGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3UVL7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3UX09

References