Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 131763..132420 | Replicon | plasmid pPS1 |
| Accession | NZ_CP017055 | ||
| Organism | Providencia stuartii strain BE2467 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | BGK56_RS21405 | Protein ID | WP_000270043.1 |
| Coordinates | 131763..132113 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BGK56_RS21410 | Protein ID | WP_000124640.1 |
| Coordinates | 132118..132420 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BGK56_RS21365 | 128237..128734 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| BGK56_RS21370 | 128737..129225 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| BGK56_RS21375 | 129322..129657 | + | 336 | WP_000683477.1 | hypothetical protein | - |
| BGK56_RS21380 | 129672..130142 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| BGK56_RS21385 | 130135..130506 | - | 372 | WP_000516918.1 | hypothetical protein | - |
| BGK56_RS21390 | 130517..130711 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| BGK56_RS21400 | 131052..131600 | - | 549 | WP_001061573.1 | hypothetical protein | - |
| BGK56_RS21405 | 131763..132113 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BGK56_RS21410 | 132118..132420 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| BGK56_RS21415 | 132447..132740 | - | 294 | WP_001239998.1 | hypothetical protein | - |
| BGK56_RS21420 | 132829..133101 | - | 273 | WP_001043046.1 | HU family DNA-binding protein | - |
| BGK56_RS21425 | 133159..133686 | - | 528 | WP_001210659.1 | thermonuclease family protein | - |
| BGK56_RS22890 | 133689..133994 | - | 306 | WP_171820680.1 | hypothetical protein | - |
| BGK56_RS21435 | 133906..134763 | - | 858 | WP_001167036.1 | hypothetical protein | - |
| BGK56_RS21440 | 134750..134980 | - | 231 | WP_000972665.1 | hypothetical protein | - |
| BGK56_RS21445 | 134980..135367 | - | 388 | Protein_169 | nitrite reductase | - |
| BGK56_RS22735 | 135364..135810 | - | 447 | WP_000919343.1 | hypothetical protein | - |
| BGK56_RS21455 | 135810..136169 | - | 360 | WP_000422769.1 | hypothetical protein | - |
| BGK56_RS21460 | 136227..136655 | - | 429 | WP_057729316.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3')-Ia | - | 1..195378 | 195378 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T65845 WP_000270043.1 NZ_CP017055:131763-132113 [Providencia stuartii]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T65845 NZ_CP017055:131763-132113 [Providencia stuartii]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT65845 WP_000124640.1 NZ_CP017055:132118-132420 [Providencia stuartii]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT65845 NZ_CP017055:132118-132420 [Providencia stuartii]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|