Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 419443..420076 | Replicon | chromosome |
| Accession | NZ_CP016988 | ||
| Organism | Vibrio cholerae strain FORC_055 isolate MFDS | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | FORC55_RS16480 | Protein ID | WP_000843587.1 |
| Coordinates | 419443..419775 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FORC55_RS16485 | Protein ID | WP_000071008.1 |
| Coordinates | 419762..420076 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC55_RS19745 | 414818..415003 | + | 186 | WP_145995864.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16445 | 415024..415257 | + | 234 | WP_002033284.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16450 | 415661..415894 | + | 234 | WP_032475975.1 | DUF3709 domain-containing protein | - |
| FORC55_RS19750 | 416083..416277 | + | 195 | WP_080286596.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16455 | 416298..416531 | + | 234 | WP_002033284.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16465 | 417276..417773 | + | 498 | WP_000259910.1 | GNAT family N-acetyltransferase | - |
| FORC55_RS16470 | 417894..418814 | + | 921 | WP_004393974.1 | IS5 family transposase | - |
| FORC55_RS16475 | 418956..419252 | + | 297 | WP_001069046.1 | hypothetical protein | - |
| FORC55_RS16480 | 419443..419775 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC55_RS16485 | 419762..420076 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| FORC55_RS16490 | 420204..420494 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC55_RS16495 | 420484..420732 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FORC55_RS16500 | 420935..421453 | + | 519 | WP_000698780.1 | GNAT family N-acetyltransferase | - |
| FORC55_RS16505 | 422093..422380 | + | 288 | WP_032475967.1 | hypothetical protein | - |
| FORC55_RS16510 | 422677..422841 | + | 165 | WP_001902694.1 | DUF645 family protein | - |
| FORC55_RS16520 | 423059..423547 | + | 489 | WP_000424241.1 | hypothetical protein | - |
| FORC55_RS16525 | 423684..424166 | + | 483 | WP_032481646.1 | GNAT family N-acetyltransferase | - |
| FORC55_RS16535 | 424366..424713 | + | 348 | WP_000885701.1 | DUF3024 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 417894..418814 | 920 | |
| - | inside | Integron | - | - | 402484..460316 | 57832 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T65781 WP_000843587.1 NZ_CP016988:419443-419775 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T65781 NZ_CP016988:419443-419775 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGACGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGACGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT65781 WP_000071008.1 NZ_CP016988:419762-420076 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT65781 NZ_CP016988:419762-420076 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|