Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 787970..788414 Replicon chromosome
Accession NZ_CP016954
Organism Cutibacterium avidum strain DPC 6544

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BFS79_RS03550 Protein ID WP_069101673.1
Coordinates 788133..788414 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BFS79_RS12965 Protein ID WP_196768490.1
Coordinates 787970..788098 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFS79_RS03525 783350..783958 - 609 WP_069101669.1 DedA family protein -
BFS79_RS03530 783982..785094 - 1113 WP_069101670.1 glycosyltransferase -
BFS79_RS03535 785100..785522 - 423 WP_069101671.1 RDD family protein -
BFS79_RS03540 785635..787056 + 1422 WP_069101672.1 type I glutamate--ammonia ligase -
BFS79_RS12965 787970..788098 - 129 WP_196768490.1 hypothetical protein Antitoxin
BFS79_RS03550 788133..788414 - 282 WP_069101673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFS79_RS03555 788816..789412 - 597 WP_065674108.1 hypothetical protein -
BFS79_RS03560 790678..791085 - 408 WP_069101674.1 DUF4232 domain-containing protein -
BFS79_RS03565 791328..792377 - 1050 WP_069101675.1 YdcF family protein -
BFS79_RS03570 792442..793044 - 603 WP_069102863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.17 Da        Isoelectric Point: 7.1358

>T65673 WP_069101673.1 NZ_CP016954:c788414-788133 [Cutibacterium avidum]
VIRSFGSTDTERVWHREGAPSMDPRILRVALRKLRQVGSAEMLEDLCVPPGNRLEALKGDRVGQHSIRINDQRRVCFRWT
DAGPEEVEIVDYY

Download         Length: 282 bp

>T65673 NZ_CP016954:c788414-788133 [Cutibacterium avidum]
GTGATCAGATCGTTCGGGAGCACGGACACCGAGCGGGTGTGGCATCGTGAGGGTGCGCCCTCCATGGATCCCCGGATCCT
CCGGGTGGCATTGCGCAAGCTTCGTCAGGTGGGATCTGCGGAGATGCTCGAGGACCTCTGCGTTCCACCCGGTAACCGAC
TCGAGGCGCTCAAGGGCGACCGAGTTGGTCAGCACAGCATCAGAATCAATGATCAGCGGCGGGTCTGTTTCAGATGGACA
GACGCCGGACCAGAGGAGGTGGAGATCGTTGACTACTACTGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4588.26 Da        Isoelectric Point: 6.4470

>AT65673 WP_196768490.1 NZ_CP016954:c788098-787970 [Cutibacterium avidum]
MEDFIEGFGVTQHNLAVSIGVPPRRINEIIHGKRGISVDTAL

Download         Length: 129 bp

>AT65673 NZ_CP016954:c788098-787970 [Cutibacterium avidum]
ATGGAGGATTTCATCGAGGGGTTCGGGGTCACGCAGCACAATCTCGCTGTGTCGATAGGTGTGCCGCCGCGGCGGATCAA
CGAGATCATACACGGCAAGCGAGGGATCTCAGTGGACACCGCATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References