Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3502074..3502726 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ATE40_RS16480 Protein ID WP_033652133.1
Coordinates 3502074..3502418 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ATE40_RS16485 Protein ID WP_025160230.1
Coordinates 3502424..3502726 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS16465 3498417..3500675 - 2259 WP_063917947.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
ATE40_RS16475 3500896..3501915 + 1020 WP_025160231.1 HTH-type transcriptional regulator GalR -
ATE40_RS16480 3502074..3502418 + 345 WP_033652133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATE40_RS16485 3502424..3502726 + 303 WP_025160230.1 helix-turn-helix transcriptional regulator Antitoxin
ATE40_RS16490 3502754..3504016 - 1263 WP_019455706.1 diaminopimelate decarboxylase -
ATE40_RS16495 3504151..3505074 + 924 WP_019455705.1 LysR family transcriptional regulator -
ATE40_RS16500 3505064..3506218 - 1155 WP_063917949.1 MFS transporter -
ATE40_RS16505 3506536..3507444 - 909 WP_019455703.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(31-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13325.36 Da        Isoelectric Point: 10.8296

>T65633 WP_033652133.1 NZ_CP016948:3502074-3502418 [Serratia surfactantfaciens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T65633 NZ_CP016948:3502074-3502418 [Serratia surfactantfaciens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACCAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGAGTGTTTTTCGCTTTTGACCCACAGCGGCAAGCG
GTGCTGTTGTGCGGTGGCGATAAAACCGGCGACAAGCGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCCACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11097.01 Da        Isoelectric Point: 10.3986

>AT65633 WP_025160230.1 NZ_CP016948:3502424-3502726 [Serratia surfactantfaciens]
MAKPLSQLIDKLDPAVVSAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT65633 NZ_CP016948:3502424-3502726 [Serratia surfactantfaciens]
ATGGCTAAACCTTTATCCCAATTGATCGACAAGCTCGATCCCGCCGTCGTTAGCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGCGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAACTGTCGTCACTCAAACGCTATATCGAGGCTATG
GGCGGCACGCTGTCGCTGGACGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References