Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2733113..2733773 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ATE40_RS12880 Protein ID WP_063919703.1
Coordinates 2733420..2733773 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ATE40_RS12875 Protein ID WP_063919702.1
Coordinates 2733113..2733415 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS12850 2728761..2729495 - 735 WP_063919698.1 SDR family oxidoreductase -
ATE40_RS12855 2729532..2730167 - 636 WP_063919699.1 SDR family oxidoreductase -
ATE40_RS12860 2730183..2731118 - 936 WP_063919700.1 alpha/beta hydrolase -
ATE40_RS12865 2731118..2732038 - 921 WP_063919701.1 alpha/beta hydrolase -
ATE40_RS12870 2732177..2733085 + 909 WP_019453564.1 LysR family transcriptional regulator -
ATE40_RS12875 2733113..2733415 - 303 WP_063919702.1 XRE family transcriptional regulator Antitoxin
ATE40_RS12880 2733420..2733773 - 354 WP_063919703.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATE40_RS12885 2734085..2734450 - 366 WP_063919704.1 diacylglycerol kinase -
ATE40_RS12890 2734669..2735793 - 1125 WP_063919705.1 GNAT family N-acetyltransferase -
ATE40_RS12895 2736535..2738274 + 1740 WP_071892015.1 fatty acyl-AMP ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2727192..2739477 12285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13492.47 Da        Isoelectric Point: 8.2467

>T65630 WP_063919703.1 NZ_CP016948:c2733773-2733420 [Serratia surfactantfaciens]
VWEIKTTDVFDNWFSSLNDAERAAVLAALMVLREKGPGLSRPYADTVKGSCYCNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T65630 NZ_CP016948:c2733773-2733420 [Serratia surfactantfaciens]
GTGTGGGAAATTAAAACAACGGATGTGTTTGATAACTGGTTTAGCTCTCTCAACGATGCCGAGCGAGCCGCAGTGCTTGC
CGCATTGATGGTTCTGCGGGAAAAAGGGCCCGGCTTGTCCAGGCCCTATGCCGATACGGTTAAAGGCTCGTGTTACTGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTGTCGGCATG
GTGCTTTGCGCGGGCAATAAAGCGGGCAATGAAAAACGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAATTGGCTGAATACACTAAAAGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11142.96 Da        Isoelectric Point: 5.1992

>AT65630 WP_063919702.1 NZ_CP016948:c2733415-2733113 [Serratia surfactantfaciens]
MGRTLEQLIADEKPEVVAEAQAMATEIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT65630 NZ_CP016948:c2733415-2733113 [Serratia surfactantfaciens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCGAAGCGCAGGCAATGGCGACGGAGAT
TATGCTGAACATCCATCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGCGCTGGGCATCA
GGCAACCGACCGTCGCCGTGATGGAAAAGCCGGGCCGCGATCTGAAGCTTTCCTCGCTCAAACGCTATGTTGAGGCGGCA
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References