Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 3686599..3687323 | Replicon | chromosome |
| Accession | NZ_CP016945 | ||
| Organism | Yersinia enterocolitica strain YE1 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | A0A7U7FJ92 |
| Locus tag | BFS78_RS17240 | Protein ID | WP_005166025.1 |
| Coordinates | 3687027..3687323 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | A0A7U7IZK5 |
| Locus tag | BFS78_RS17235 | Protein ID | WP_049527936.1 |
| Coordinates | 3686599..3687027 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BFS78_RS17210 | 3681918..3683162 | - | 1245 | WP_049527926.1 | sensor domain-containing diguanylate cyclase | - |
| BFS78_RS17215 | 3683245..3683640 | - | 396 | WP_005166615.1 | SgcJ/EcaC family oxidoreductase | - |
| BFS78_RS17220 | 3684012..3684959 | - | 948 | Protein_3379 | Fic family protein | - |
| BFS78_RS17225 | 3684977..3685177 | + | 201 | WP_049527931.1 | AlpA family transcriptional regulator | - |
| BFS78_RS17230 | 3685320..3686522 | + | 1203 | WP_049527934.1 | IS256 family transposase | - |
| BFS78_RS17235 | 3686599..3687027 | - | 429 | WP_049527936.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| BFS78_RS17240 | 3687027..3687323 | - | 297 | WP_005166025.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| BFS78_RS17245 | 3687480..3687842 | - | 363 | WP_005166026.1 | helix-turn-helix domain-containing protein | - |
| BFS78_RS17250 | 3687908..3688168 | - | 261 | WP_005166028.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BFS78_RS17255 | 3688665..3689696 | - | 1032 | Protein_3386 | IS630 family transposase | - |
| BFS78_RS17260 | 3690252..3691472 | + | 1221 | WP_049527941.1 | tyrosine-type recombinase/integrase | - |
| BFS78_RS17265 | 3691548..3691922 | - | 375 | WP_049527943.1 | hypothetical protein | - |
| BFS78_RS23260 | 3691919..3692128 | - | 210 | WP_049527946.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 3680480..3689696 | 9216 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11322.18 Da Isoelectric Point: 7.7766
>T65612 WP_005166025.1 NZ_CP016945:c3687323-3687027 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL
Download Length: 297 bp
>T65612 NZ_CP016945:c3687323-3687027 [Yersinia enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA
Antitoxin
Download Length: 143 a.a. Molecular weight: 16029.82 Da Isoelectric Point: 9.1221
>AT65612 WP_049527936.1 NZ_CP016945:c3687027-3686599 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM
Download Length: 429 bp
>AT65612 NZ_CP016945:c3687027-3686599 [Yersinia enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7FJ92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7IZK5 |