Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 3612054..3612778 | Replicon | chromosome |
| Accession | NZ_CP016940 | ||
| Organism | Yersinia enterocolitica strain YE5 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | A0A7U7FJ92 |
| Locus tag | BED32_RS17290 | Protein ID | WP_005166025.1 |
| Coordinates | 3612482..3612778 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | A0A7U7IZK5 |
| Locus tag | BED32_RS17285 | Protein ID | WP_049527936.1 |
| Coordinates | 3612054..3612482 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BED32_RS17260 | 3607373..3608617 | - | 1245 | WP_049527926.1 | sensor domain-containing diguanylate cyclase | - |
| BED32_RS17265 | 3608700..3609095 | - | 396 | WP_005166615.1 | SgcJ/EcaC family oxidoreductase | - |
| BED32_RS17270 | 3609467..3610414 | - | 948 | Protein_3306 | Fic family protein | - |
| BED32_RS17275 | 3610432..3610632 | + | 201 | WP_049527931.1 | AlpA family transcriptional regulator | - |
| BED32_RS17280 | 3610775..3611977 | + | 1203 | WP_049527934.1 | IS256 family transposase | - |
| BED32_RS17285 | 3612054..3612482 | - | 429 | WP_049527936.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| BED32_RS17290 | 3612482..3612778 | - | 297 | WP_005166025.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| BED32_RS17295 | 3612935..3613297 | - | 363 | WP_005166026.1 | helix-turn-helix domain-containing protein | - |
| BED32_RS17300 | 3613363..3613623 | - | 261 | WP_005166028.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BED32_RS17305 | 3614120..3615151 | - | 1032 | Protein_3313 | IS630 family transposase | - |
| BED32_RS17310 | 3615707..3616927 | + | 1221 | WP_049527941.1 | tyrosine-type recombinase/integrase | - |
| BED32_RS17315 | 3617003..3617377 | - | 375 | WP_049527943.1 | hypothetical protein | - |
| BED32_RS17320 | 3617374..3617583 | - | 210 | WP_049527946.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 3605935..3615151 | 9216 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11322.18 Da Isoelectric Point: 7.7766
>T65575 WP_005166025.1 NZ_CP016940:c3612778-3612482 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL
Download Length: 297 bp
>T65575 NZ_CP016940:c3612778-3612482 [Yersinia enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA
Antitoxin
Download Length: 143 a.a. Molecular weight: 16029.82 Da Isoelectric Point: 9.1221
>AT65575 WP_049527936.1 NZ_CP016940:c3612482-3612054 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM
Download Length: 429 bp
>AT65575 NZ_CP016940:c3612482-3612054 [Yersinia enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7FJ92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7IZK5 |