Detailed information of TA system TA065535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3679634..3680358
• Replicon: chromosome
• Accession: NZ_CP016935
• Organism: Yersinia enterocolitica strain YE7

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A7U7FJ92
• Locus tag: BED34_RS17685
• Protein ID: WP_005166025.1
• Coordinates: 3680062..3680358 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A7U7IZK5
• Locus tag: BED34_RS17680
• Protein ID: WP_049527936.1
• Coordinates: 3679634..3680062 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BED34_RS17655	3674953..3676197	-	1245	WP_049527926.1	sensor domain-containing diguanylate cyclase	-
BED34_RS17660	3676280..3676675	-	396	WP_005166615.1	SgcJ/EcaC family oxidoreductase	-
BED34_RS17665	3677047..3677994	-	948	Protein_3371	Fic family protein	-
BED34_RS17670	3678012..3678212	+	201	WP_049527931.1	AlpA family transcriptional regulator	-
BED34_RS17675	3678355..3679557	+	1203	WP_049527934.1	IS256 family transposase	-
BED34_RS17680	3679634..3680062	-	429	WP_049527936.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BED34_RS17685	3680062..3680358	-	297	WP_005166025.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BED34_RS17690	3680515..3680877	-	363	WP_005166026.1	helix-turn-helix domain-containing protein	-
BED34_RS17695	3680943..3681203	-	261	WP_005166028.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BED34_RS17700	3681700..3682731	-	1032	Protein_3378	IS630 family transposase	-
BED34_RS17705	3683287..3684507	+	1221	WP_049527941.1	tyrosine-type recombinase/integrase	-
BED34_RS17710	3684583..3684957	-	375	WP_049527943.1	hypothetical protein	-
BED34_RS17715	3684954..3685163	-	210	WP_049527946.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3673515..3682731	9216

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (4-132)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11322.18 Da
• Isoelectric Point: 7.7766

>T65535 WP_005166025.1 NZ_CP016935:c3680358-3680062 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T65535 NZ_CP016935:c3680358-3680062 [Yersinia enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16029.82 Da
• Isoelectric Point: 9.1221

>AT65535 WP_049527936.1 NZ_CP016935:c3680062-3679634 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM

Nucleotide

• Length: 429 bp

>AT65535 NZ_CP016935:c3680062-3679634 [Yersinia enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FJ92

Antitoxin

• AlphaFold DB: A0A7U7IZK5