Detailed information of TA system TA065520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4358476..4358978
• Replicon: chromosome
• Accession: NZ_CP016931
• Organism: Yersinia enterocolitica strain YE165

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BB936_RS20130
• Protein ID: WP_049528435.1
• Coordinates: 4358476..4358730 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7U7IZ70
• Locus tag: BB936_RS20135
• Protein ID: WP_049528437.1
• Coordinates: 4358727..4358978 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB936_RS20120	4353600..4355698	-	2099	Protein_3940	TonB-dependent siderophore receptor	-
BB936_RS20125	4356117..4358452	+	2336	Protein_3941	mechanosensitive ion channel family protein	-
BB936_RS20130	4358476..4358730	-	255	WP_049528435.1	Txe/YoeB family addiction module toxin	Toxin
BB936_RS20135	4358727..4358978	-	252	WP_049528437.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
BB936_RS20140	4359109..4361894	-	2786	Protein_3944	insulinase family protein	-
BB936_RS20145	4361879..4363624	-	1746	WP_162489085.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10098.54 Da
• Isoelectric Point: 8.4816

>T65520 WP_049528435.1 NZ_CP016931:c4358730-4358476 [Yersinia enterocolitica]
VRIIFSSCSWEDYLYWQQTDKEILKRINELVKNIQRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYEVSGDNLLIAAC
RYHY

Nucleotide

• Length: 255 bp

>T65520 NZ_CP016931:c4358730-4358476 [Yersinia enterocolitica]
GTGAGAATTATATTTTCCAGTTGTTCTTGGGAGGATTATCTTTATTGGCAACAAACGGATAAGGAAATCCTCAAACGCAT
TAATGAGTTAGTAAAAAATATTCAAAGAACGCCATTTGAGGGAAAGGGTAAACCGGAACCCCTTAAACATAATCTGGCAG
GGTTCTGGTCACGGAGGATTACAGAAGAGCACAGACTTGTTTATGAGGTTTCCGGTGATAATTTATTAATTGCTGCTTGT
CGTTACCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.66 Da
• Isoelectric Point: 4.4878

>AT65520 WP_049528437.1 NZ_CP016931:c4358978-4358727 [Yersinia enterocolitica]
MRTISYSEARQNLSTTMVQTVEDRAPILITRQNGTSCVLMSLEEYESLEETAYLLRSPSNAKHLMDSIEELRAGKGIQRE
LEE

Nucleotide

• Length: 252 bp

>AT65520 NZ_CP016931:c4358978-4358727 [Yersinia enterocolitica]
ATGAGAACAATTAGTTATAGTGAGGCGCGCCAGAATTTGTCGACAACGATGGTGCAAACGGTTGAGGATCGAGCCCCCAT
CCTCATCACTCGTCAAAATGGGACTTCTTGTGTTCTTATGTCACTTGAAGAATATGAATCATTGGAAGAAACTGCTTATT
TACTGCGCTCACCATCAAACGCGAAGCATTTGATGGACTCAATTGAAGAGTTGAGAGCAGGAAAAGGAATTCAAAGGGAA
CTTGAAGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U7IZ70