Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3861982..3862706 Replicon chromosome
Accession NZ_CP016931
Organism Yersinia enterocolitica strain YE165

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7U7FJ92
Locus tag BB936_RS18025 Protein ID WP_005166025.1
Coordinates 3862410..3862706 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A7U7IZK5
Locus tag BB936_RS18020 Protein ID WP_049527936.1
Coordinates 3861982..3862410 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB936_RS17995 3857301..3858545 - 1245 WP_049527926.1 sensor domain-containing diguanylate cyclase -
BB936_RS18000 3858628..3859023 - 396 WP_005166615.1 SgcJ/EcaC family oxidoreductase -
BB936_RS18005 3859395..3860342 - 948 Protein_3527 Fic family protein -
BB936_RS18010 3860360..3860560 + 201 WP_005166614.1 AlpA family transcriptional regulator -
BB936_RS18015 3860703..3861905 + 1203 WP_049527934.1 IS256 family transposase -
BB936_RS18020 3861982..3862410 - 429 WP_049527936.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BB936_RS18025 3862410..3862706 - 297 WP_005166025.1 type II toxin-antitoxin system MqsR family toxin Toxin
BB936_RS18030 3862863..3863225 - 363 WP_005166026.1 helix-turn-helix domain-containing protein -
BB936_RS18035 3863291..3863551 - 261 WP_005166028.1 type II toxin-antitoxin system RelE/ParE family toxin -
BB936_RS18040 3864048..3865079 - 1032 Protein_3534 IS630 family transposase -
BB936_RS18050 3865763..3867280 - 1518 WP_013649344.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3860703..3865079 4376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA

(4-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11322.18 Da        Isoelectric Point: 7.7766

>T65517 WP_005166025.1 NZ_CP016931:c3862706-3862410 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Download         Length: 297 bp

>T65517 NZ_CP016931:c3862706-3862410 [Yersinia enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 16029.82 Da        Isoelectric Point: 9.1221

>AT65517 WP_049527936.1 NZ_CP016931:c3862410-3861982 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM

Download         Length: 429 bp

>AT65517 NZ_CP016931:c3862410-3861982 [Yersinia enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJ92

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7IZK5

References