Detailed information of TA system TA065396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1842948..1843593
• Replicon: chromosome
• Accession: NZ_CP016889
• Organism: Pantoea agglomerans strain C410P1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BEE12_RS08315
• Protein ID: WP_033787535.1
• Coordinates: 1842948..1843301 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BEE12_RS08320
• Protein ID: WP_022625233.1
• Coordinates: 1843294..1843593 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BEE12_RS08295	1838805..1839770	-	966	WP_010252125.1	AraC family transcriptional regulator	-
BEE12_RS08300	1839875..1841062	+	1188	WP_064704970.1	MFS transporter	-
BEE12_RS08305	1841275..1841484	+	210	WP_009092571.1	DUF1471 domain-containing protein	-
BEE12_RS08310	1841686..1842738	+	1053	WP_069025645.1	YncE family protein	-
BEE12_RS08315	1842948..1843301	+	354	WP_033787535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BEE12_RS08320	1843294..1843593	+	300	WP_022625233.1	helix-turn-helix transcriptional regulator	Antitoxin
BEE12_RS08325	1843641..1844882	-	1242	WP_010672044.1	peptide antibiotic transporter SbmA	-
BEE12_RS08330	1845159..1845893	+	735	WP_069025646.1	gluconate 2-dehydrogenase subunit 3 family protein	-
BEE12_RS08335	1845896..1847680	+	1785	WP_010252112.1	GMC family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1833322..1843593	10271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13421.31 Da
• Isoelectric Point: 6.4741

>T65396 WP_033787535.1 NZ_CP016889:1842948-1843301 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG

Nucleotide

• Length: 354 bp

>T65396 NZ_CP016889:1842948-1843301 [Pantoea agglomerans]
ATGTGGGATGTGGATACAACCAAAAGATTTGATGAATGGTTTAAGGCTCAGACTGAGGAACTGAAGGAGGATATGCTCGC
CGCGATAGTTATCCTGTCTGAGTATGGGCCGCATTTAGCGAGGCCGTTTGCTGATACTGTAGACGGCTCTGATTTTCCGA
ATATGAAAGAATTAAGAGTGCAGCATCAAGGCAAACCGATACGGGCCTTCTTTGCTTTTGATCCTTCTCGCCGCGGCATT
GTGTTGTGTGCAGGCGATAAAACCGGGGTTAAGGAAAAGAAATTCTATAAAGACATGATCAAATTGGCAGATGCTGAATT
CCGCAAATATTTGAATGGAGGGGATAATGGCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11131.98 Da
• Isoelectric Point: 9.8103

>AT65396 WP_022625233.1 NZ_CP016889:1843294-1843593 [Pantoea agglomerans]
MANLKELMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL

Nucleotide

• Length: 300 bp

>AT65396 NZ_CP016889:1843294-1843593 [Pantoea agglomerans]
ATGGCTAATTTAAAAGAGCTGATGGCAAATCAAAGTCCGGAGAGTCGCGAACGCATTGCCAAAAAAGTCGATGCAATGCG
GCAGGTTATCGCGCTACACATGTTGCGCGAAGAACTTAATCTGTCACAGACAGAGATGGCGCATGCAATGGGTGTGAAAC
AGCCAACTATCGCCAGAATGGAACAGGCTGATAATGATCCCCGCCTTTCTACGCTGAAGCGTTACGTTACGGCTCTGGGA
GGCGAGATAAGTATCGATGTCAAATTGCCGACAGGCAAAAGAATAGCTTTTGATCTGTGA