Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3509833..3510422 Replicon chromosome
Accession NZ_CP016878
Organism Xanthomonas hortorum strain B07-007

Toxin (Protein)


Gene name graT Uniprot ID A0A6V7BZM8
Locus tag XJ27_RS16015 Protein ID WP_074058684.1
Coordinates 3510141..3510422 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Q5FN17
Locus tag XJ27_RS16010 Protein ID WP_055829449.1
Coordinates 3509833..3510123 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ27_RS23830 3505262..3506587 + 1326 WP_154845000.1 hypothetical protein -
XJ27_RS15990 3506980..3507312 + 333 WP_074058681.1 hypothetical protein -
XJ27_RS16000 3507930..3508748 - 819 WP_197970278.1 AraC family transcriptional regulator -
XJ27_RS16005 3508967..3509710 + 744 WP_074058683.1 SDR family oxidoreductase -
XJ27_RS16010 3509833..3510123 - 291 WP_055829449.1 HigA family addiction module antidote protein Antitoxin
XJ27_RS16015 3510141..3510422 - 282 WP_074058684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XJ27_RS16020 3510637..3511692 - 1056 WP_074058685.1 virulence RhuM family protein -
XJ27_RS16025 3511831..3514074 - 2244 WP_095575051.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.71 Da        Isoelectric Point: 10.2121

>T65332 WP_074058684.1 NZ_CP016878:c3510422-3510141 [Xanthomonas hortorum]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVAEVDIVDYH

Download         Length: 282 bp

>T65332 NZ_CP016878:c3510422-3510141 [Xanthomonas hortorum]
ATGATAAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGTTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGTATTCCACCTGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGACGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGACATCGTCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10497.17 Da        Isoelectric Point: 6.4675

>AT65332 WP_055829449.1 NZ_CP016878:c3510123-3509833 [Xanthomonas hortorum]
MTVLPNIHPGEILLEEFLEPMGISQNALARATAVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEEA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT65332 NZ_CP016878:c3510123-3509833 [Xanthomonas hortorum]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATCCTGCTTGAGGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGCCGTGCCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCCGCAGCGCTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGACTACGAGCTGGAAGAAGCG
CACCGCGCGCTGGGCGACCTGCCGTCACGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7BZM8

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q5FN17

References