Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 743130..743645 Replicon chromosome
Accession NZ_CP016878
Organism Xanthomonas hortorum strain B07-007

Toxin (Protein)


Gene name higB Uniprot ID A0A1L5Y3A2
Locus tag XJ27_RS03190 Protein ID WP_006450902.1
Coordinates 743130..743336 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6V7E8T8
Locus tag XJ27_RS03195 Protein ID WP_074057535.1
Coordinates 743346..743645 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ27_RS03165 738450..739700 - 1251 WP_074057536.1 chemotaxis protein CheW -
XJ27_RS03170 739697..740479 - 783 WP_006452730.1 ParA family protein -
XJ27_RS03175 740481..741470 - 990 WP_006452731.1 flagellar motor protein MotD -
XJ27_RS03180 741478..742218 - 741 WP_006452732.1 flagellar motor protein -
XJ27_RS03190 743130..743336 + 207 WP_006450902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XJ27_RS03195 743346..743645 + 300 WP_074057535.1 HigA family addiction module antidote protein Antitoxin
XJ27_RS03200 743788..745446 - 1659 WP_055826896.1 chemotaxis protein CheA -
XJ27_RS03205 745449..746075 - 627 WP_006450905.1 protein phosphatase CheZ -
XJ27_RS03210 746075..746467 - 393 WP_002813536.1 chemotaxis response regulator CheY -
XJ27_RS03215 746503..747276 - 774 WP_023903918.1 RNA polymerase sigma factor FliA -
XJ27_RS03220 747273..748157 - 885 WP_006451802.1 MinD/ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-67)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7818.83 Da        Isoelectric Point: 6.2041

>T65329 WP_006450902.1 NZ_CP016878:743130-743336 [Xanthomonas hortorum]
MQAVAERKLQLLDSAQTLEFLRSPPGNRFELLAGTRAGQHSIRINDQWRVCFVWTDAGPEHVEIVDYH

Download         Length: 207 bp

>T65329 NZ_CP016878:743130-743336 [Xanthomonas hortorum]
ATGCAAGCTGTAGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAA
TCGGTTTGAGCTTCTTGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCT
GGACTGACGCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10900.54 Da        Isoelectric Point: 10.7753

>AT65329 WP_074057535.1 NZ_CP016878:743346-743645 [Xanthomonas hortorum]
MRPNNKLRAIHPGEILREDFMLPLGLTINGLARALDVPATRIHSIVHGERAISADTAARLARHFGGDAASWLALQATYEL
KTLPNRSEIERNVQPRVAA

Download         Length: 300 bp

>AT65329 NZ_CP016878:743346-743645 [Xanthomonas hortorum]
ATGCGACCCAACAACAAACTGCGCGCCATCCATCCCGGCGAAATCCTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATTAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCAGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTGCAGGCCACGTATGAACTC
AAGACCTTGCCCAACCGCAGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5Y3A2

Antitoxin

Source ID Structure
AlphaFold DB A0A6V7E8T8

References