Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1019339..1019521 Replicon chromosome
Accession NZ_CP016863
Organism Staphylococcus aureus strain 1625.C01

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag A7Q05_RS15305 Protein ID WP_001801861.1
Coordinates 1019426..1019521 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1019339..1019398 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7Q05_RS05805 1018477..1018854 + 378 WP_001037045.1 DUF1433 domain-containing protein -
A7Q05_RS05810 1019048..1019224 + 177 Protein_1018 transposase -
A7Q05_RS05815 1019202..1019303 - 102 WP_001791893.1 hypothetical protein -
- 1019339..1019398 + 60 - - Antitoxin
A7Q05_RS15305 1019426..1019521 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
A7Q05_RS05825 1019724..1019867 + 144 WP_001549059.1 transposase -
A7Q05_RS05835 1020471..1020854 + 384 WP_000070811.1 hypothetical protein -
A7Q05_RS05840 1020865..1021041 + 177 WP_000375476.1 hypothetical protein -
A7Q05_RS05845 1021043..1021228 + 186 WP_000809857.1 hypothetical protein -
A7Q05_RS05850 1021342..1021983 + 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
A7Q05_RS05855 1022201..1022752 - 552 WP_000414205.1 hypothetical protein -
A7Q05_RS05860 1022850..1023194 - 345 WP_000627551.1 DUF3969 family protein -
A7Q05_RS05865 1023235..1023861 - 627 Protein_1028 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlgA / lukD 986250..1045560 59310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T65305 WP_001801861.1 NZ_CP016863:c1019521-1019426 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T65305 NZ_CP016863:c1019521-1019426 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT65305 NZ_CP016863:1019339-1019398 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References