Detailed information of TA system TA065301

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 858293..858631
• Replicon: chromosome
• Accession: NZ_CP016863
• Organism: Staphylococcus aureus strain 1625.C01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7Q05_RS04750
• Protein ID: WP_011447039.1
• Coordinates: 858293..858469 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	858457..858631 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7Q05_RS04730	853528..857313	+	3786	WP_000582165.1	hypothetical protein	-
A7Q05_RS04735	857303..857455	+	153	WP_001153681.1	hypothetical protein	-
A7Q05_RS04740	857502..857789	+	288	WP_001040261.1	hypothetical protein	-
A7Q05_RS04745	857847..858143	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
A7Q05_RS04750	858293..858469	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	858457..858631	-	175	-	-	Antitoxin
A7Q05_RS04760	858681..858935	+	255	WP_000611512.1	phage holin	-
A7Q05_RS04765	858947..859702	+	756	WP_000861038.1	CHAP domain-containing protein	-
A7Q05_RS04770	859893..860384	+	492	WP_000919350.1	staphylokinase	-
A7Q05_RS04780	861034..861369	+	336	Protein_866	SH3 domain-containing protein	-
A7Q05_RS04785	861464..861913	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
A7Q05_RS04790	862598..862948	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7Q05_RS04795	863001..863261	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	803981..862948	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T65301 WP_011447039.1 NZ_CP016863:858293-858469 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T65301 NZ_CP016863:858293-858469 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT65301 NZ_CP016863:c858631-858457 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin