Detailed information of TA system TA065292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 393682..393866
• Replicon: chromosome
• Accession: NZ_CP016863
• Organism: Staphylococcus aureus strain 1625.C01

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: A7Q05_RS02145
• Protein ID: WP_000482650.1
• Coordinates: 393682..393789 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	393806..393866 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7Q05_RS02120	389044..389517	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
A7Q05_RS02125	389640..390851	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
A7Q05_RS02130	391033..391692	-	660	WP_000831298.1	membrane protein	-
A7Q05_RS02135	391752..392894	-	1143	WP_001176863.1	glycerate kinase	-
A7Q05_RS02140	393162..393548	+	387	WP_000779358.1	flippase GtxA	-
A7Q05_RS02145	393682..393789	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	393806..393866	-	61	-	-	Antitoxin
A7Q05_RS02155	394417..396180	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
A7Q05_RS02160	396205..397938	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
A7Q05_RS02170	398169..398336	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T65292 WP_000482650.1 NZ_CP016863:393682-393789 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T65292 NZ_CP016863:393682-393789 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT65292 NZ_CP016863:c393866-393806 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin