Detailed information of TA system TA065285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2153655..2153993
• Replicon: chromosome
• Accession: NZ_CP016861
• Organism: Staphylococcus aureus strain 1969.N

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7U52_RS11515
• Protein ID: WP_011447039.1
• Coordinates: 2153655..2153831 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2153819..2153993 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7U52_RS11495	2148890..2152675	+	3786	WP_000582165.1	hypothetical protein	-
A7U52_RS11500	2152665..2152817	+	153	WP_001153681.1	hypothetical protein	-
A7U52_RS11505	2152864..2153151	+	288	WP_001040261.1	hypothetical protein	-
A7U52_RS11510	2153209..2153505	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
A7U52_RS11515	2153655..2153831	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2153819..2153993	-	175	-	-	Antitoxin
A7U52_RS11525	2154043..2154297	+	255	WP_000611512.1	phage holin	-
A7U52_RS11530	2154309..2155064	+	756	WP_000861038.1	CHAP domain-containing protein	-
A7U52_RS11535	2155255..2155746	+	492	WP_000919350.1	staphylokinase	-
A7U52_RS11545	2156396..2156731	+	336	Protein_2099	SH3 domain-containing protein	-
A7U52_RS11550	2156826..2157275	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
A7U52_RS11555	2157960..2158310	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7U52_RS11560	2158363..2158623	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2102362..2158310	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T65285 WP_011447039.1 NZ_CP016861:2153655-2153831 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T65285 NZ_CP016861:2153655-2153831 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT65285 NZ_CP016861:c2153993-2153819 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin