Detailed information of TA system TA065268

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2162522..2162860
• Replicon: chromosome
• Accession: NZ_CP016858
• Organism: Staphylococcus aureus strain 1971.C01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7U47_RS11505
• Protein ID: WP_011447039.1
• Coordinates: 2162522..2162698 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2162686..2162860 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7U47_RS11485	2157757..2161542	+	3786	WP_000582165.1	hypothetical protein	-
A7U47_RS11490	2161532..2161684	+	153	WP_001153681.1	hypothetical protein	-
A7U47_RS11495	2161731..2162018	+	288	WP_001040261.1	hypothetical protein	-
A7U47_RS11500	2162076..2162372	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
A7U47_RS11505	2162522..2162698	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2162686..2162860	-	175	-	-	Antitoxin
A7U47_RS11515	2162910..2163164	+	255	WP_000611512.1	phage holin	-
A7U47_RS11520	2163176..2163931	+	756	WP_000861038.1	CHAP domain-containing protein	-
A7U47_RS11525	2164122..2164613	+	492	WP_000919350.1	staphylokinase	-
A7U47_RS11535	2165263..2165598	+	336	Protein_2121	SH3 domain-containing protein	-
A7U47_RS11540	2165693..2166142	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
A7U47_RS11545	2166827..2167177	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7U47_RS11550	2167230..2167490	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	2122178..2167177	44999

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T65268 WP_011447039.1 NZ_CP016858:2162522-2162698 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T65268 NZ_CP016858:2162522-2162698 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT65268 NZ_CP016858:c2162860-2162686 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin