Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1987939..1988202 Replicon chromosome
Accession NZ_CP016858
Organism Staphylococcus aureus strain 1971.C01

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A7U47_RS10485 Protein ID WP_001802298.1
Coordinates 1987939..1988043 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 1988038..1988202 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U47_RS10460 1983323..1984105 + 783 WP_000908176.1 ABC transporter ATP-binding protein -
A7U47_RS10465 1984173..1985030 + 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
A7U47_RS10470 1985735..1985827 - 93 WP_001790138.1 hypothetical protein -
A7U47_RS10475 1986116..1987252 + 1137 WP_000115564.1 SAP domain-containing protein -
A7U47_RS15515 1987295..1987778 + 484 Protein_1923 recombinase family protein -
A7U47_RS10485 1987939..1988043 + 105 WP_001802298.1 hypothetical protein Toxin
- 1988038..1988202 - 165 - - Antitoxin
A7U47_RS10490 1988543..1989634 - 1092 WP_000495671.1 lytic regulatory protein -
A7U47_RS10495 1989900..1990880 - 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
A7U47_RS10500 1990882..1991202 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
A7U47_RS10505 1991354..1992019 + 666 WP_001024094.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T65262 WP_001802298.1 NZ_CP016858:1987939-1988043 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T65262 NZ_CP016858:1987939-1988043 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT65262 NZ_CP016858:c1988202-1988038 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References