Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1697916..1698100 Replicon chromosome
Accession NZ_CP016858
Organism Staphylococcus aureus strain 1971.C01

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag A7U47_RS08900 Protein ID WP_000482650.1
Coordinates 1697916..1698023 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1698040..1698100 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U47_RS08875 1693278..1693751 + 474 WP_000456489.1 GyrI-like domain-containing protein -
A7U47_RS08880 1693874..1695085 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
A7U47_RS08885 1695267..1695926 - 660 WP_000831298.1 membrane protein -
A7U47_RS08890 1695986..1697128 - 1143 WP_001176863.1 glycerate kinase -
A7U47_RS08895 1697396..1697782 + 387 WP_000779358.1 flippase GtxA -
A7U47_RS08900 1697916..1698023 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1698040..1698100 - 61 - - Antitoxin
A7U47_RS08910 1698651..1700414 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
A7U47_RS08915 1700439..1702172 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
A7U47_RS08925 1702403..1702570 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T65259 WP_000482650.1 NZ_CP016858:1697916-1698023 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T65259 NZ_CP016858:1697916-1698023 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT65259 NZ_CP016858:c1698100-1698040 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References