Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1666076..1666599 Replicon chromosome
Accession NZ_CP016858
Organism Staphylococcus aureus strain 1971.C01

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag A7U47_RS08740 Protein ID WP_000074048.1
Coordinates 1666333..1666599 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag A7U47_RS08735 Protein ID WP_000587616.1
Coordinates 1666076..1666333 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U47_RS08710 1661156..1662349 + 1194 WP_000675401.1 MFS transporter -
A7U47_RS08715 1662573..1663322 - 750 WP_000072444.1 hypothetical protein -
A7U47_RS08720 1663517..1665094 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
A7U47_RS08725 1665262..1665717 - 456 WP_000732082.1 DUF1307 domain-containing protein -
A7U47_RS08730 1665776..1665970 + 195 WP_001790145.1 hypothetical protein -
A7U47_RS08735 1666076..1666333 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7U47_RS08740 1666333..1666599 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
A7U47_RS08745 1666954..1668030 + 1077 WP_001076671.1 M42 family metallopeptidase -
A7U47_RS08750 1668278..1668940 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
A7U47_RS08755 1668933..1669709 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
A7U47_RS08760 1670105..1671292 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T65258 WP_000074048.1 NZ_CP016858:1666333-1666599 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T65258 NZ_CP016858:1666333-1666599 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT65258 WP_000587616.1 NZ_CP016858:1666076-1666333 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT65258 NZ_CP016858:1666076-1666333 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References