Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1691434..1691618 Replicon chromosome
Accession NZ_CP016856
Organism Staphylococcus aureus strain 2148.N

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag A7U44_RS08455 Protein ID WP_000482650.1
Coordinates 1691434..1691541 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1691558..1691618 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U44_RS08430 1686806..1687279 + 474 WP_000456489.1 GyrI-like domain-containing protein -
A7U44_RS08435 1687402..1688613 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
A7U44_RS08440 1688795..1689454 - 660 WP_000831298.1 membrane protein -
A7U44_RS08445 1689514..1690656 - 1143 WP_001176863.1 glycerate kinase -
A7U44_RS08450 1690914..1691300 + 387 WP_000779358.1 flippase GtxA -
A7U44_RS08455 1691434..1691541 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1691558..1691618 - 61 - - Antitoxin
A7U44_RS08465 1692189..1693952 + 1764 WP_001064820.1 ABC transporter ATP-binding protein/permease -
A7U44_RS08470 1693977..1695710 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
A7U44_RS08480 1695941..1696108 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T65242 WP_000482650.1 NZ_CP016856:1691434-1691541 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T65242 NZ_CP016856:1691434-1691541 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT65242 NZ_CP016856:c1691618-1691558 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References