Detailed information of TA system TA065241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1659914..1660437
• Replicon: chromosome
• Accession: NZ_CP016856
• Organism: Staphylococcus aureus strain 2148.N

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: A7U44_RS08295
• Protein ID: WP_000074043.1
• Coordinates: 1660171..1660437 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: A7U44_RS08290
• Protein ID: WP_000587618.1
• Coordinates: 1659914..1660171 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7U44_RS08270	1656410..1657159	-	750	WP_000072441.1	hypothetical protein	-
A7U44_RS08275	1657354..1658931	+	1578	WP_000143508.1	FMN-binding glutamate synthase family protein	-
A7U44_RS08280	1659099..1659554	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
A7U44_RS08290	1659914..1660171	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A7U44_RS08295	1660171..1660437	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
A7U44_RS08300	1660793..1661869	+	1077	WP_001076665.1	M42 family metallopeptidase	-
A7U44_RS08305	1662117..1662779	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
A7U44_RS08310	1662772..1663548	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
A7U44_RS08315	1663944..1665131	+	1188	WP_000026187.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T65241 WP_000074043.1 NZ_CP016856:1660171-1660437 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T65241 NZ_CP016856:1660171-1660437 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT65241 WP_000587618.1 NZ_CP016856:1659914-1660171 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT65241 NZ_CP016856:1659914-1660171 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2