Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2389215..2389399 Replicon chromosome
Accession NZ_CP016855
Organism Staphylococcus aureus strain 5118.N

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag A7U51_RS12600 Protein ID WP_000482650.1
Coordinates 2389215..2389322 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2389339..2389399 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U51_RS12575 2384577..2385050 + 474 WP_000456489.1 GyrI-like domain-containing protein -
A7U51_RS12580 2385173..2386384 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
A7U51_RS12585 2386566..2387225 - 660 WP_000831298.1 membrane protein -
A7U51_RS12590 2387285..2388427 - 1143 WP_001176863.1 glycerate kinase -
A7U51_RS12595 2388695..2389081 + 387 WP_000779358.1 flippase GtxA -
A7U51_RS12600 2389215..2389322 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2389339..2389399 - 61 - - Antitoxin
A7U51_RS12610 2389950..2391713 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
A7U51_RS12615 2391738..2393471 + 1734 WP_109885764.1 ABC transporter ATP-binding protein/permease -
A7U51_RS12625 2393702..2393869 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T65228 WP_000482650.1 NZ_CP016855:2389215-2389322 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T65228 NZ_CP016855:2389215-2389322 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT65228 NZ_CP016855:c2389399-2389339 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References