Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4154483..4155024 Replicon chromosome
Accession NZ_CP016828
Organism Escherichia coli strain FORC_043

Toxin (Protein)


Gene name yafQ Uniprot ID B7LHF6
Locus tag FORC43_RS22095 Protein ID WP_000615974.1
Coordinates 4154746..4155024 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag FORC43_RS22090 Protein ID WP_000729704.1
Coordinates 4154483..4154743 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC43_RS22065 4150266..4151051 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
FORC43_RS22070 4151023..4152735 + 1713 Protein_4025 flagellar biosynthesis protein FlhA -
FORC43_RS22075 4152840..4153118 + 279 WP_000598758.1 type II toxin-antitoxin system HicA family toxin -
FORC43_RS22080 4153111..4153467 + 357 WP_001030479.1 type II toxin-antitoxin system HicB family antitoxin -
FORC43_RS22085 4153524..4154297 - 774 WP_000543895.1 C40 family peptidase -
FORC43_RS22090 4154483..4154743 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
FORC43_RS22095 4154746..4155024 + 279 WP_000615974.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
FORC43_RS22100 4155180..4155920 + 741 WP_001225679.1 murein L,D-transpeptidase -
FORC43_RS22105 4155891..4156658 - 768 WP_000333380.1 class II glutamine amidotransferase -
FORC43_RS22110 4156864..4157442 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10855.68 Da        Isoelectric Point: 10.2267

>T65177 WP_000615974.1 NZ_CP016828:4154746-4155024 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMRLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T65177 NZ_CP016828:4154746-4155024 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGAGGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT65177 WP_000729704.1 NZ_CP016828:4154483-4154743 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT65177 NZ_CP016828:4154483-4154743 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y514


Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References