Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1661424..1661938 Replicon chromosome
Accession NZ_CP016803
Organism Limosilactobacillus fermentum strain SK152

Toxin (Protein)


Gene name yoeB Uniprot ID D0DT30
Locus tag BEP11_RS08370 Protein ID WP_004562989.1
Coordinates 1661675..1661938 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D0DT29
Locus tag BEP11_RS08365 Protein ID WP_004562988.1
Coordinates 1661424..1661678 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEP11_RS08350 1656815..1657654 + 840 WP_049184706.1 PRD domain-containing protein -
BEP11_RS08355 1657762..1659741 + 1980 WP_087908097.1 beta-glucoside-specific PTS transporter subunit IIABC -
BEP11_RS08360 1659787..1661262 + 1476 WP_087908098.1 family 1 glycosylhydrolase -
BEP11_RS08365 1661424..1661678 + 255 WP_004562988.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BEP11_RS08370 1661675..1661938 + 264 WP_004562989.1 Txe/YoeB family addiction module toxin Toxin
BEP11_RS08375 1662108..1663229 - 1122 WP_087908099.1 PTS sugar transporter subunit IIC -
BEP11_RS08380 1663644..1664567 - 924 WP_087908421.1 IS30 family transposase -
BEP11_RS08385 1664775..1665689 - 915 WP_087907934.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10304.04 Da        Isoelectric Point: 10.4974

>T65094 WP_004562989.1 NZ_CP016803:1661675-1661938 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSRYE

Download         Length: 264 bp

>T65094 NZ_CP016803:1661675-1661938 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGTCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACGTTACGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9730.97 Da        Isoelectric Point: 4.3108

>AT65094 WP_004562988.1 NZ_CP016803:1661424-1661678 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQINERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT65094 NZ_CP016803:1661424-1661678 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAATGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0CGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A843QZ89

References