Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1992852..1993366 Replicon chromosome
Accession NZ_CP016795
Organism Streptomyces olivaceus strain KLBMP 5084

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6G9ES44
Locus tag BC342_RS08810 Protein ID WP_031030578.1
Coordinates 1993112..1993366 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6G9ESD1
Locus tag BC342_RS08805 Protein ID WP_031030581.1
Coordinates 1992852..1993115 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC342_RS08795 1988686..1989546 + 861 WP_070387895.1 phosphatase PAP2 family protein -
BC342_RS08800 1989689..1992700 - 3012 WP_070387896.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
BC342_RS08805 1992852..1993115 + 264 WP_031030581.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BC342_RS08810 1993112..1993366 + 255 WP_031030578.1 Txe/YoeB family addiction module toxin Toxin
BC342_RS08815 1993451..1993897 + 447 WP_037764594.1 VOC family protein -
BC342_RS08820 1993925..1995697 - 1773 WP_070387897.1 NAD+ synthase -
BC342_RS08825 1995875..1996504 - 630 WP_070387898.1 DUF305 domain-containing protein -
BC342_RS08830 1996501..1997169 - 669 WP_070387899.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9911.23 Da        Isoelectric Point: 9.7377

>T65093 WP_031030578.1 NZ_CP016795:1993112-1993366 [Streptomyces olivaceus]
VRVTFTSHGWEDYVHWAESDRKVTKRINRLIDDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADGVLVIVQA
RYHY

Download         Length: 255 bp

>T65093 NZ_CP016795:1993112-1993366 [Streptomyces olivaceus]
GTGAGGGTCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGACGACATCACCCGTGACCCGTTCAAGGGCATCGGGAAGCCGGAGCCGCTCAAGGGCGACCTGTCGG
GCTACTGGTCACGGCGCATCGACGACACGCACCGGCTCGTGTACAAGCCCGCCGACGGCGTACTGGTCATCGTGCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9784.92 Da        Isoelectric Point: 4.8784

>AT65093 WP_031030581.1 NZ_CP016795:1992852-1993115 [Streptomyces olivaceus]
MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT65093 NZ_CP016795:1992852-1993115 [Streptomyces olivaceus]
ATGCCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCATGCCCCGGTACA
CATCACCTCCCGCAAGGGAAACGCCGTACTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTCCTGC
GCTCGCCCAAGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAAGCGGGCGAAGCACGGCATCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9ES44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9ESD1

References