Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2012733..2013243 Replicon chromosome
Accession NZ_CP016760
Organism Staphylococcus carnosus strain LTH 3730 SK 13 JCM 6069

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag BEK99_RS10035 Protein ID WP_012664284.1
Coordinates 2012733..2013002 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag BEK99_RS10040 Protein ID WP_012664283.1
Coordinates 2012995..2013243 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEK99_RS10015 2007779..2008681 - 903 WP_053464280.1 ABC transporter substrate-binding protein -
BEK99_RS10020 2008813..2010477 - 1665 WP_065865778.1 arginine--tRNA ligase -
BEK99_RS10025 2010479..2010895 - 417 WP_046100211.1 DUF1934 family protein -
BEK99_RS10030 2011056..2012246 - 1191 WP_065865779.1 amidohydrolase -
BEK99_RS10035 2012733..2013002 - 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
BEK99_RS10040 2012995..2013243 - 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BEK99_RS10045 2013583..2014995 - 1413 Protein_1973 PLP-dependent aminotransferase family protein -
BEK99_RS13425 2015169..2015538 + 370 Protein_1974 fatty acid desaturase -
BEK99_RS10055 2015745..2016362 + 618 WP_012664281.1 LysE family transporter -
BEK99_RS10060 2016546..2017058 - 513 WP_012664280.1 YwhD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T65029 WP_012664284.1 NZ_CP016760:c2013002-2012733 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T65029 NZ_CP016760:c2013002-2012733 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT65029 WP_012664283.1 NZ_CP016760:c2013243-2012995 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT65029 NZ_CP016760:c2013243-2012995 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References