Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4409538..4410077 Replicon chromosome
Accession NZ_CP016755
Organism Escherichia coli strain FORC_044

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag FORC44_RS24105 Protein ID WP_001303998.1
Coordinates 4409817..4410077 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag FORC44_RS24100 Protein ID WP_000729705.1
Coordinates 4409538..4409798 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC44_RS24080 4405292..4406077 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
FORC44_RS24085 4406049..4407761 + 1713 Protein_4376 flagellar biosynthesis protein FlhA -
FORC44_RS24090 4407906..4408403 - 498 Protein_4377 REP-associated tyrosine transposase RayT -
FORC44_RS24095 4408579..4409352 - 774 WP_000543891.1 C40 family peptidase -
FORC44_RS24100 4409538..4409798 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
FORC44_RS24105 4409817..4410077 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
FORC44_RS24110 4410233..4410973 + 741 WP_001225679.1 murein L,D-transpeptidase -
FORC44_RS24115 4410944..4411711 - 768 WP_001301698.1 class II glutamine amidotransferase -
FORC44_RS24120 4411816..4412394 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-85)

Antitoxin

(1-85)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T65015 WP_001303998.1 NZ_CP016755:4409817-4410077 [Escherichia coli]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T65015 NZ_CP016755:4409817-4410077 [Escherichia coli]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT65015 WP_000729705.1 NZ_CP016755:4409538-4409798 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT65015 NZ_CP016755:4409538-4409798 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References