65010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3237998..3238793 Replicon chromosome
Accession NZ_CP016755
Organism Escherichia coli strain FORC_044

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag FORC44_RS17840 Protein ID WP_000854914.1
Coordinates 3237998..3238372 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag FORC44_RS17845 Protein ID WP_001280954.1
Coordinates 3238419..3238793 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC44_RS17800 3233002..3233493 - 492 WP_001301587.1 DUF1097 domain-containing protein -
FORC44_RS17805 3233595..3234149 - 555 WP_001001917.1 molecular chaperone YcdY -
FORC44_RS17810 3234173..3234910 - 738 WP_000283664.1 zinc-binding phosphatase -
FORC44_RS17815 3234965..3235903 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
FORC44_RS17825 3236374..3237216 - 843 WP_001280481.1 DUF4942 domain-containing protein -
FORC44_RS17830 3237301..3237498 - 198 WP_000839282.1 DUF957 domain-containing protein -
FORC44_RS17835 3237510..3238001 - 492 WP_000976853.1 hypothetical protein -
FORC44_RS17840 3237998..3238372 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
FORC44_RS17845 3238419..3238793 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FORC44_RS17855 3238956..3239177 - 222 WP_001220314.1 DUF987 domain-containing protein -
FORC44_RS17860 3239240..3239716 - 477 WP_001186738.1 RadC family protein -
FORC44_RS17865 3239732..3240217 - 486 WP_000214398.1 antirestriction protein -
FORC44_RS17870 3240308..3241126 - 819 WP_001234682.1 DUF945 domain-containing protein -
FORC44_RS17885 3241466..3242536 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
FORC44_RS17890 3242533..3243438 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3229384..3240217 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T65010 WP_000854914.1 NZ_CP016755:c3238372-3237998 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T65010 NZ_CP016755:c3238372-3237998 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT65010 WP_001280954.1 NZ_CP016755:c3238793-3238419 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT65010 NZ_CP016755:c3238793-3238419 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References