Detailed information of TA system TA064987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1580932..1581446
• Replicon: chromosome
• Accession: NZ_CP016753
• Organism: Leptotrichia sp. oral taxon 498 strain F0590

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BCB68_RS07925
• Protein ID: WP_094080285.1
• Coordinates: 1581189..1581446 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U2RIH6
• Locus tag: BCB68_RS07920
• Protein ID: WP_021766441.1
• Coordinates: 1580932..1581189 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCB68_RS07900	1576541..1577419	+	879	WP_094080281.1	hypothetical protein	-
BCB68_RS07905	1577861..1578079	+	219	WP_094080282.1	hypothetical protein	-
BCB68_RS07910	1578104..1579120	+	1017	WP_094080283.1	hypothetical protein	-
BCB68_RS07915	1579222..1580610	-	1389	WP_094080284.1	MATE family efflux transporter	-
BCB68_RS07920	1580932..1581189	+	258	WP_021766441.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BCB68_RS07925	1581189..1581446	+	258	WP_094080285.1	Txe/YoeB family addiction module toxin	Toxin
BCB68_RS07930	1581702..1582679	+	978	WP_157697376.1	hypothetical protein	-
BCB68_RS07935	1583023..1584228	+	1206	WP_094080286.1	sel1 repeat family protein	-
BCB68_RS07940	1584247..1584489	+	243	WP_094080287.1	hypothetical protein	-
BCB68_RS07945	1584558..1585004	+	447	WP_094080288.1	hypothetical protein	-
BCB68_RS07950	1584976..1585197	+	222	WP_094080289.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10187.73 Da
• Isoelectric Point: 10.0379

>T64987 WP_094080285.1 NZ_CP016753:1581189-1581446 [Leptotrichia sp. oral taxon 498]
MNLTWTDIAWGQYEEWQRQDKKIVKKINEIIKDIKRNGNEGIGKPEPLKHELNGYWSRRITDKHRFIYKLTETSILVIAC
ANHHK

Nucleotide

• Length: 258 bp

>T64987 NZ_CP016753:1581189-1581446 [Leptotrichia sp. oral taxon 498]
ATGAATTTAACATGGACAGATATTGCATGGGGGCAATATGAAGAATGGCAGAGACAGGATAAAAAAATAGTCAAAAAAAT
AAATGAAATAATAAAAGACATCAAAAGAAACGGAAATGAAGGGATAGGGAAACCTGAGCCTTTAAAGCATGAACTGAATG
GATACTGGAGCAGAAGAATTACTGATAAACACAGGTTTATATATAAACTAACAGAAACAAGTATACTAGTTATTGCCTGT
GCAAATCATCATAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9986.26 Da
• Isoelectric Point: 4.6535

>AT64987 WP_021766441.1 NZ_CP016753:1580932-1581189 [Leptotrichia sp. oral taxon 498]
MIATNYSNVRNNLKKYCDKATDDYETVIITRKNDKNVVLMSEEEYNNLMENLYIMSNKKYYNELLKSKAEAEAGNVQIHD
IIEVE

Nucleotide

• Length: 258 bp

>AT64987 NZ_CP016753:1580932-1581189 [Leptotrichia sp. oral taxon 498]
ATGATAGCTACAAATTATTCAAATGTGAGAAATAATTTAAAAAAATATTGTGATAAGGCAACTGATGATTATGAAACAGT
CATTATAACAAGAAAAAACGATAAAAATGTGGTACTGATGAGTGAAGAGGAATATAATAATTTGATGGAAAATCTTTACA
TCATGTCAAATAAGAAATACTATAATGAACTGTTAAAAAGTAAAGCGGAAGCGGAAGCGGGGAATGTACAAATACATGAT
ATAATTGAGGTGGAATAA

Structures

Antitoxin

• AlphaFold DB: U2RIH6