Detailed information of TA system TA064979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1139906..1140503
• Replicon: chromosome
• Accession: NZ_CP016678
• Organism: Neisseria meningitidis strain M25419

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L86_RS06150
• Protein ID: WP_002242826.1
• Coordinates: 1140225..1140503 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L86_RS06145
• Protein ID: WP_002221020.1
• Coordinates: 1139906..1140217 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L86_RS13700	1135824..1135988	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
A6L86_RS06130	1135988..1136599	+	612	WP_042744707.1	baseplate J/gp47 family protein	-
A6L86_RS06135	1136596..1137156	+	561	WP_002213590.1	YmfQ family protein	-
A6L86_RS06140	1137167..1139140	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L86_RS06145	1139906..1140217	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L86_RS06150	1140225..1140503	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L86_RS06155	1140588..1141193	+	606	WP_002219301.1	hypothetical protein	-
A6L86_RS06160	1141172..1141468	+	297	WP_002221017.1	hypothetical protein	-
A6L86_RS06165	1141465..1141674	+	210	WP_002222487.1	hypothetical protein	-
A6L86_RS06170	1141784..1142927	-	1144	Protein_1163	ABC transporter ATP-binding protein/permease	-
A6L86_RS06185	1143216..1143863	-	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L86_RS06190	1143860..1144228	-	369	WP_002234874.1	DUF4810 domain-containing protein	-
A6L86_RS06195	1144238..1144909	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1124845..1141468	16623
	-	flank	IS/Tn	-	-	1134794..1135759	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64979 WP_002242826.1 NZ_CP016678:c1140503-1140225 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64979 NZ_CP016678:c1140503-1140225 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64979 WP_002221020.1 NZ_CP016678:c1140217-1139906 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64979 NZ_CP016678:c1140217-1139906 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6