Detailed information of TA system TA064978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1117973..1118570
• Replicon: chromosome
• Accession: NZ_CP016677
• Organism: Neisseria meningitidis strain M25456

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L95_RS06030
• Protein ID: WP_002242826.1
• Coordinates: 1118292..1118570 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L95_RS06025
• Protein ID: WP_002221020.1
• Coordinates: 1117973..1118284 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L95_RS13515	1113904..1114068	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
A6L95_RS06010	1114068..1114679	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6L95_RS06015	1114676..1115236	+	561	WP_002213590.1	YmfQ family protein	-
A6L95_RS06020	1115247..1117220	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L95_RS06025	1117973..1118284	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L95_RS06030	1118292..1118570	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L95_RS06035	1118655..1119260	+	606	WP_002219301.1	hypothetical protein	-
A6L95_RS06040	1119239..1119535	+	297	WP_002221017.1	hypothetical protein	-
A6L95_RS06045	1119532..1119741	+	210	WP_002222487.1	hypothetical protein	-
A6L95_RS06050	1119851..1120994	-	1144	Protein_1137	ABC transporter ATP-binding protein/permease	-
A6L95_RS06065	1121436..1122083	-	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L95_RS06070	1122080..1122448	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6L95_RS06075	1122458..1123129	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1103677..1119535	15858
	-	flank	IS/Tn	-	-	1112874..1113839	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64978 WP_002242826.1 NZ_CP016677:c1118570-1118292 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64978 NZ_CP016677:c1118570-1118292 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64978 WP_002221020.1 NZ_CP016677:c1118284-1117973 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64978 NZ_CP016677:c1118284-1117973 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6