Detailed information of TA system TA064977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 384227..384824
• Replicon: chromosome
• Accession: NZ_CP016676
• Organism: Neisseria meningitidis strain M25476

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6M07_RS01890
• Protein ID: WP_002242826.1
• Coordinates: 384227..384505 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6M07_RS01895
• Protein ID: WP_002221020.1
• Coordinates: 384513..384824 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6M07_RS01845	379668..380339	+	672	WP_002217215.1	CsgG/HfaB family protein	-
A6M07_RS01850	380349..380717	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6M07_RS01855	380714..381361	+	648	WP_002217218.1	DUF799 domain-containing protein	-
A6M07_RS01870	381803..382946	+	1144	Protein_349	ABC transporter ATP-binding protein/permease	-
A6M07_RS01875	383056..383265	-	210	WP_002222487.1	hypothetical protein	-
A6M07_RS01880	383262..383558	-	297	WP_002221017.1	hypothetical protein	-
A6M07_RS01885	383537..384142	-	606	WP_002219301.1	hypothetical protein	-
A6M07_RS01890	384227..384505	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6M07_RS01895	384513..384824	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6M07_RS01900	385565..387538	-	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6M07_RS01905	387549..388109	-	561	WP_002213590.1	YmfQ family protein	-
A6M07_RS01910	388106..388717	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6M07_RS13235	388717..388881	-	165	WP_002224559.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	383262..396763	13501
	-	flank	IS/Tn	-	-	388946..389911	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64977 WP_002242826.1 NZ_CP016676:384227-384505 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64977 NZ_CP016676:384227-384505 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64977 WP_002221020.1 NZ_CP016676:384513-384824 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64977 NZ_CP016676:384513-384824 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6