Detailed information of TA system TA064972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1015855..1016452
• Replicon: chromosome
• Accession: NZ_CP016669
• Organism: Neisseria meningitidis strain M22759

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L38_RS05410
• Protein ID: WP_002242826.1
• Coordinates: 1016174..1016452 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L38_RS05405
• Protein ID: WP_002221020.1
• Coordinates: 1015855..1016166 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L38_RS13465	1011760..1011924	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
A6L38_RS05390	1011924..1012535	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6L38_RS05395	1012532..1013092	+	561	WP_002213590.1	YmfQ family protein	-
A6L38_RS05400	1013103..1015076	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L38_RS05405	1015855..1016166	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L38_RS05410	1016174..1016452	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L38_RS05415	1016537..1017142	+	606	WP_002219301.1	hypothetical protein	-
A6L38_RS05420	1017121..1017417	+	297	WP_002221017.1	hypothetical protein	-
A6L38_RS05425	1017414..1017623	+	210	WP_002222487.1	hypothetical protein	-
A6L38_RS05430	1017733..1018876	-	1144	Protein_1022	ABC transporter ATP-binding protein/permease	-
A6L38_RS05445	1019318..1019965	-	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L38_RS05450	1019962..1020330	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6L38_RS05455	1020340..1021011	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1003878..1017417	13539
	-	flank	IS/Tn	-	-	1010730..1011695	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64972 WP_002242826.1 NZ_CP016669:c1016452-1016174 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64972 NZ_CP016669:c1016452-1016174 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64972 WP_002221020.1 NZ_CP016669:c1016166-1015855 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64972 NZ_CP016669:c1016166-1015855 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6