Detailed information of TA system TA064970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1861676..1862273
• Replicon: chromosome
• Accession: NZ_CP016667
• Organism: Neisseria meningitidis strain M27559

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6M08_RS09460
• Protein ID: WP_002242826.1
• Coordinates: 1861676..1861954 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6M08_RS09465
• Protein ID: WP_079870528.1
• Coordinates: 1861962..1862273 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6M08_RS09415	1857117..1857788	+	672	WP_002217215.1	CsgG/HfaB family protein	-
A6M08_RS09420	1857798..1858166	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6M08_RS09425	1858163..1858810	+	648	WP_002217218.1	DUF799 domain-containing protein	-
A6M08_RS09440	1859252..1860395	+	1144	Protein_1756	ABC transporter ATP-binding protein/permease	-
A6M08_RS09445	1860505..1860714	-	210	WP_002222487.1	hypothetical protein	-
A6M08_RS09450	1860711..1861007	-	297	WP_002221017.1	hypothetical protein	-
A6M08_RS09455	1860986..1861591	-	606	WP_002219301.1	hypothetical protein	-
A6M08_RS09460	1861676..1861954	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6M08_RS09465	1861962..1862273	+	312	WP_079870528.1	HigA family addiction module antidote protein	Antitoxin
A6M08_RS09470	1863014..1864987	-	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6M08_RS09475	1864998..1865558	-	561	WP_002213590.1	YmfQ family protein	-
A6M08_RS09480	1865555..1866166	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6M08_RS13690	1866166..1866330	-	165	WP_002224559.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1860711..1876557	15846
	-	flank	IS/Tn	-	-	1866395..1867360	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64970 WP_002242826.1 NZ_CP016667:1861676-1861954 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64970 NZ_CP016667:1861676-1861954 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11433.30 Da
• Isoelectric Point: 10.2202

>AT64970 WP_079870528.1 NZ_CP016667:1861962-1862273 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSLVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64970 NZ_CP016667:1861962-1862273 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCTGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6