Detailed information of TA system TA064968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1762599..1763196
• Replicon: chromosome
• Accession: NZ_CP016665
• Organism: Neisseria meningitidis strain M09261

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L26_RS09210
• Protein ID: WP_002242826.1
• Coordinates: 1762918..1763196 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L26_RS09205
• Protein ID: WP_002221020.1
• Coordinates: 1762599..1762910 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L26_RS13590	1758516..1758680	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
A6L26_RS09190	1758680..1759291	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6L26_RS09195	1759288..1759848	+	561	WP_002213590.1	YmfQ family protein	-
A6L26_RS09200	1759859..1761832	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L26_RS09205	1762599..1762910	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L26_RS09210	1762918..1763196	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L26_RS09215	1763281..1763886	+	606	WP_002219301.1	hypothetical protein	-
A6L26_RS09220	1763865..1764161	+	297	WP_002221017.1	hypothetical protein	-
A6L26_RS09225	1764158..1764367	+	210	WP_002222487.1	hypothetical protein	-
A6L26_RS09230	1764477..1765620	-	1144	Protein_1718	ABC transporter ATP-binding protein/permease	-
A6L26_RS09245	1766062..1766709	-	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L26_RS09250	1766706..1767074	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6L26_RS09255	1767084..1767755	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1750634..1764161	13527
	-	flank	IS/Tn	-	-	1757486..1758451	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64968 WP_002242826.1 NZ_CP016665:c1763196-1762918 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64968 NZ_CP016665:c1763196-1762918 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64968 WP_002221020.1 NZ_CP016665:c1762910-1762599 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64968 NZ_CP016665:c1762910-1762599 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6