Detailed information of TA system TA064964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1561107..1561704
• Replicon: chromosome
• Accession: NZ_CP016661
• Organism: Neisseria meningitidis strain M25438

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L93_RS07915
• Protein ID: WP_002242826.1
• Coordinates: 1561107..1561385 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L93_RS07920
• Protein ID: WP_002221020.1
• Coordinates: 1561393..1561704 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L93_RS07870	1556548..1557219	+	672	WP_002217215.1	CsgG/HfaB family protein	-
A6L93_RS07875	1557229..1557597	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6L93_RS07880	1557594..1558241	+	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L93_RS07895	1558683..1559826	+	1144	Protein_1456	ABC transporter ATP-binding protein/permease	-
A6L93_RS07900	1559936..1560145	-	210	WP_002222487.1	hypothetical protein	-
A6L93_RS07905	1560142..1560438	-	297	WP_002221017.1	hypothetical protein	-
A6L93_RS07910	1560417..1561022	-	606	WP_002219301.1	hypothetical protein	-
A6L93_RS07915	1561107..1561385	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L93_RS07920	1561393..1561704	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L93_RS07925	1562445..1564418	-	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L93_RS07930	1564429..1564989	-	561	WP_002213590.1	YmfQ family protein	-
A6L93_RS07935	1564986..1565597	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6L93_RS13575	1565597..1565761	-	165	WP_002224559.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1560142..1575988	15846
	-	flank	IS/Tn	-	-	1565826..1566791	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64964 WP_002242826.1 NZ_CP016661:1561107-1561385 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64964 NZ_CP016661:1561107-1561385 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64964 WP_002221020.1 NZ_CP016661:1561393-1561704 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64964 NZ_CP016661:1561393-1561704 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6