Detailed information of TA system TA064953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1855784..1856381
• Replicon: chromosome
• Accession: NZ_CP016648
• Organism: Neisseria meningitidis strain M09293

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: A6L27_RS09445
• Protein ID: WP_002242826.1
• Coordinates: 1855784..1856062 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A6L27_RS09450
• Protein ID: WP_002221020.1
• Coordinates: 1856070..1856381 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6L27_RS09400	1851225..1851896	+	672	WP_002217215.1	CsgG/HfaB family protein	-
A6L27_RS09405	1851906..1852274	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
A6L27_RS09410	1852271..1852918	+	648	WP_002217218.1	DUF799 domain-containing protein	-
A6L27_RS09425	1853360..1854503	+	1144	Protein_1754	ABC transporter ATP-binding protein/permease	-
A6L27_RS09430	1854613..1854822	-	210	WP_002222487.1	hypothetical protein	-
A6L27_RS09435	1854819..1855115	-	297	WP_002221017.1	hypothetical protein	-
A6L27_RS09440	1855094..1855699	-	606	WP_002219301.1	hypothetical protein	-
A6L27_RS09445	1855784..1856062	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6L27_RS09450	1856070..1856381	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
A6L27_RS09455	1857135..1859108	-	1974	WP_002248050.1	pyocin knob domain-containing protein	-
A6L27_RS09460	1859119..1859679	-	561	WP_002213590.1	YmfQ family protein	-
A6L27_RS09465	1859676..1860287	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
A6L27_RS13655	1860287..1860451	-	165	WP_002224559.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1854819..1868333	13514
	-	flank	IS/Tn	-	-	1860516..1861481	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T64953 WP_002242826.1 NZ_CP016648:1855784-1856062 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64953 NZ_CP016648:1855784-1856062 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT64953 WP_002221020.1 NZ_CP016648:1856070-1856381 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT64953 NZ_CP016648:1856070-1856381 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6