Detailed information of TA system TA064803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1390608..1391174
• Replicon: chromosome
• Accession: NZ_CP016553
• Organism: Aggregatibacter actinomycetemcomitans strain IDH781

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JU35
• Locus tag: BBH51_RS06775
• Protein ID: WP_005543444.1
• Coordinates: 1390608..1390886 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: BBH51_RS06780
• Protein ID: WP_005543446.1
• Coordinates: 1390902..1391174 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBH51_RS06750	1386166..1386720	+	555	WP_005543432.1	HAD family hydrolase	-
BBH51_RS06755	1386886..1388433	+	1548	WP_005554440.1	anthranilate synthase component 1	-
BBH51_RS06760	1388444..1389034	+	591	WP_005543437.1	aminodeoxychorismate/anthranilate synthase component II	-
BBH51_RS06765	1389108..1389500	+	393	WP_005543439.1	tautomerase family protein	-
BBH51_RS06770	1389512..1390513	+	1002	WP_005543441.1	anthranilate phosphoribosyltransferase	-
BBH51_RS06775	1390608..1390886	+	279	WP_005543444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBH51_RS06780	1390902..1391174	+	273	WP_005543446.1	HigA family addiction module antidote protein	Antitoxin
BBH51_RS06785	1391183..1392613	+	1431	WP_005543449.1	bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF	-
BBH51_RS06790	1392752..1393037	+	286	Protein_1342	hydrogenase	-
BBH51_RS06795	1393067..1393342	+	276	WP_005561117.1	hydrogenase maturation factor HybG	-
BBH51_RS06800	1393463..1393840	-	378	WP_005543455.1	hypothetical protein	-
BBH51_RS11425	1393815..1394006	-	192	WP_005553960.1	hypothetical protein	-
BBH51_RS06805	1394367..1394633	+	267	WP_005543457.1	oxaloacetate decarboxylase subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-79)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10490.95 Da
• Isoelectric Point: 9.5983

>T64803 WP_005543444.1 NZ_CP016553:1390608-1390886 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T64803 NZ_CP016553:1390608-1390886 [Aggregatibacter actinomycetemcomitans]
ATGATTTTATCTTTCAAACATAAGGGACTTGAACAATTTTTTAAAACCGGTTCGACCGCAGGAATTCAAGCCAAACACGC
CAAGAAATTAAATCTGCAATTGGCCACATTAAATAATGCGGAAACGCCTCTTGCTATGAGTGTTCCCAGCTGGAATTTGC
ACAAACTTAAAGGTGATTTGCAAGAGCATTGGGCAGTTACCGTAAACGGAAATTGGCGCTTAACATTTAAATTTGAAAAT
GGTCATGCTGAAGTTGTTGATTATCAGGATTATCATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10138.74 Da
• Isoelectric Point: 7.3169

>AT64803 WP_005543446.1 NZ_CP016553:1390902-1391174 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Nucleotide

• Length: 273 bp

>AT64803 NZ_CP016553:1390902-1391174 [Aggregatibacter actinomycetemcomitans]
ATGCACAATCCTCCACACCCGGGAGAACTGTTAAAAGAATATATTGATGGCGTGAGTGTCACGAAGGTTGCCCAAAAATT
AGGTGTTTCGCGTGTTACGCTTTCCCGCATTCTTAATGGGAAAGCAAGTATAACGCCTGAAATGGCTGTGCGATTAAGCG
AATTATTGAATACCACAACACCGAAATTATGGCTGGGTATGCAAGCAGACTACGATTTATGGCAAATTGAACAACAACAC
GCCGTATTCAACATCCAACCATTATTTAATTAA

Structures

Toxin

• AlphaFold DB: X2JU35