Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2699687..2700189 Replicon chromosome
Accession NZ_CP016474
Organism Synechococcus sp. PCC 7003

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1B1TS29
Locus tag AWQ21_RS12775 Protein ID WP_065714868.1
Coordinates 2699687..2699941 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B1TS38
Locus tag AWQ21_RS12780 Protein ID WP_065714869.1
Coordinates 2699938..2700189 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ21_RS12760 2695423..2695692 - 270 WP_198159657.1 hypothetical protein -
AWQ21_RS12765 2695729..2696814 + 1086 WP_065714866.1 3-isopropylmalate dehydrogenase -
AWQ21_RS12770 2697019..2699613 + 2595 WP_065714867.1 ATP-dependent chaperone ClpB -
AWQ21_RS12775 2699687..2699941 - 255 WP_065714868.1 Txe/YoeB family addiction module toxin Toxin
AWQ21_RS12780 2699938..2700189 - 252 WP_065714869.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
AWQ21_RS12785 2700277..2703599 - 3323 Protein_2545 Eco57I restriction-modification methylase domain-containing protein -
AWQ21_RS12790 2703784..2704617 + 834 WP_065714870.1 DUF3598 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.64 Da        Isoelectric Point: 10.1244

>T64682 WP_065714868.1 NZ_CP016474:c2699941-2699687 [Synechococcus sp. PCC 7003]
MKLVFAKNAWDDYLYWQKTDKKILRRINGLIKEILRTPYEGTGKPEPLKHALSGYWSRRITAEHRLAYRVTEAAVEIAQC
RYHY

Download         Length: 255 bp

>T64682 NZ_CP016474:c2699941-2699687 [Synechococcus sp. PCC 7003]
ATGAAATTGGTGTTTGCAAAAAATGCCTGGGACGACTATCTCTATTGGCAAAAAACCGATAAAAAGATTCTGCGGCGCAT
CAACGGTTTAATCAAGGAAATTTTGCGCACCCCCTACGAAGGAACAGGCAAACCCGAACCCCTGAAGCACGCCTTATCCG
GCTACTGGTCGCGTCGAATTACCGCTGAACATCGCCTTGCTTACCGGGTAACTGAAGCTGCTGTAGAAATCGCCCAATGC
CGCTACCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.60 Da        Isoelectric Point: 4.5822

>AT64682 WP_065714869.1 NZ_CP016474:c2700189-2699938 [Synechococcus sp. PCC 7003]
MKAISYTNARQNLAKTMEQVCQDHAPVIVTRKNNDAVVIMSLEDYEALEETAYLIRSPQNAKRLLEAIAQLEGGQGLEKD
LLE

Download         Length: 252 bp

>AT64682 NZ_CP016474:c2700189-2699938 [Synechococcus sp. PCC 7003]
ATGAAAGCCATATCCTATACCAATGCCCGTCAAAATCTCGCCAAAACCATGGAGCAGGTGTGCCAAGACCATGCCCCAGT
CATCGTCACCCGGAAAAATAATGACGCGGTTGTGATTATGTCCCTCGAAGACTACGAAGCCCTAGAGGAAACGGCCTACT
TAATCCGTTCTCCCCAAAATGCCAAGCGACTACTAGAGGCGATCGCCCAACTCGAAGGTGGTCAAGGGTTAGAAAAGGAT
TTGCTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1TS29

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1TS38

References