Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 360821..361440 Replicon chromosome
Accession NZ_CP016474
Organism Synechococcus sp. PCC 7003

Toxin (Protein)


Gene name higB Uniprot ID A0A1B1TLJ2
Locus tag AWQ21_RS01700 Protein ID WP_065713047.1
Coordinates 360821..361147 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B1TLJ3
Locus tag AWQ21_RS01705 Protein ID WP_065713048.1
Coordinates 361144..361440 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ21_RS01680 357243..357461 - 219 WP_065713043.1 hypothetical protein -
AWQ21_RS01685 357529..358578 - 1050 WP_065713044.1 class 1 fructose-bisphosphatase -
AWQ21_RS01690 358819..360336 + 1518 WP_065713045.1 4-alpha-glucanotransferase -
AWQ21_RS01695 360337..360720 + 384 WP_065713046.1 DUF1818 family protein -
AWQ21_RS01700 360821..361147 + 327 WP_065713047.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWQ21_RS01705 361144..361440 + 297 WP_065713048.1 helix-turn-helix domain-containing protein Antitoxin
AWQ21_RS01710 361537..361755 + 219 WP_065713049.1 hypothetical protein -
AWQ21_RS01715 362158..362985 + 828 WP_083998042.1 NERD domain-containing protein -
AWQ21_RS01720 362971..364611 - 1641 WP_198159674.1 rhomboid family intramembrane serine protease -
AWQ21_RS01725 364696..365628 + 933 WP_065713051.1 putative selenate ABC transporter substrate-binding protein -
AWQ21_RS01730 365712..366107 - 396 WP_065713052.1 lactoylglutathione lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-88)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12404.62 Da        Isoelectric Point: 10.0733

>T64677 WP_065713047.1 NZ_CP016474:360821-361147 [Synechococcus sp. PCC 7003]
MSWSIEYPYSDVEEFVLELPPSLAAKYFRLTDLMLEFGAHLGMPHTRSMSGGLFELRVKGREGIARVFYCTLVGQRIVML
HGFVKKSQKTPSKELKIAKYRMSEVKSK

Download         Length: 327 bp

>T64677 NZ_CP016474:360821-361147 [Synechococcus sp. PCC 7003]
ATGTCTTGGAGCATTGAATACCCTTACTCTGATGTCGAAGAGTTTGTCCTTGAACTCCCACCGAGTTTAGCAGCCAAGTA
TTTTCGCCTTACAGATCTAATGCTAGAGTTTGGTGCTCATCTCGGTATGCCCCATACCCGATCTATGTCAGGCGGCTTAT
TTGAACTTCGCGTTAAAGGTAGAGAGGGGATTGCACGAGTATTCTACTGCACGCTAGTAGGACAACGGATCGTCATGCTC
CATGGCTTTGTGAAAAAATCCCAAAAGACTCCATCGAAGGAACTCAAAATCGCTAAATACCGTATGTCGGAGGTCAAGAG
TAAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10792.50 Da        Isoelectric Point: 9.1727

>AT64677 WP_065713048.1 NZ_CP016474:361144-361440 [Synechococcus sp. PCC 7003]
MNHAELKKKVLTNPETCIMYDNMEAEFSLLRQMLKARQEAGLSQAEVAARMGTKAPAVTRLESSLSSGKHSPSLATLRRY
AQAVGCELQITLVKSENI

Download         Length: 297 bp

>AT64677 NZ_CP016474:361144-361440 [Synechococcus sp. PCC 7003]
ATGAATCATGCTGAATTGAAAAAAAAGGTATTGACTAATCCTGAAACATGCATTATGTACGACAACATGGAAGCTGAGTT
TTCCTTGTTGAGACAAATGCTCAAAGCGAGACAAGAAGCTGGTCTTTCTCAAGCGGAGGTTGCTGCTCGCATGGGAACTA
AAGCCCCTGCTGTCACACGGCTAGAATCATCTCTTAGTAGTGGCAAGCATTCACCTTCTTTGGCAACCCTACGTCGTTAT
GCTCAGGCCGTAGGTTGTGAGCTTCAAATAACACTAGTCAAGTCCGAAAATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1TLJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1TLJ3

References