Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2494694..2495309 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name higB Uniprot ID A0A1D7ZNQ1
Locus tag BBJ41_RS29005 Protein ID WP_069749625.1
Coordinates 2494968..2495309 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1D7ZNQ6
Locus tag BBJ41_RS29000 Protein ID WP_069749624.1
Coordinates 2494694..2494981 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS40725 2490143..2490286 - 144 Protein_2197 5'/3'-nucleotidase SurE -
BBJ41_RS28970 2490324..2491103 - 780 WP_069749620.1 5'/3'-nucleotidase SurE -
BBJ41_RS28975 2491284..2491592 - 309 WP_069749621.1 AzlD family protein -
BBJ41_RS28980 2491585..2492319 - 735 WP_069749622.1 AzlC family ABC transporter permease -
BBJ41_RS28985 2492445..2492903 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
BBJ41_RS28990 2493124..2493693 + 570 WP_069750418.1 hypothetical protein -
BBJ41_RS28995 2493936..2494625 + 690 WP_069749623.1 YebB family permuted papain-like enzyme -
BBJ41_RS29000 2494694..2494981 - 288 WP_069749624.1 helix-turn-helix transcriptional regulator Antitoxin
BBJ41_RS29005 2494968..2495309 - 342 WP_069749625.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBJ41_RS29010 2495525..2496157 - 633 WP_069749626.1 LysE family translocator -
BBJ41_RS39745 2496421..2497437 - 1017 WP_156814889.1 fimbrial protein -
BBJ41_RS29015 2497528..2500188 - 2661 WP_069749627.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13194.44 Da        Isoelectric Point: 10.0644

>T64640 WP_069749625.1 NZ_CP016443:c2495309-2494968 [Burkholderia stabilis]
MPTVEYEIRFFSERVEADIFALPKTLTARFFALSDRMERYGPNLGEPHTRSMGDGLYEMRLKGLEGIARVFYCAVVNRRI
VMLHCFVKKTPKTPPKELETARRRLKEIRDGNL

Download         Length: 342 bp

>T64640 NZ_CP016443:c2495309-2494968 [Burkholderia stabilis]
ATGCCAACCGTCGAATATGAAATCCGTTTTTTCAGTGAACGCGTCGAGGCTGACATTTTTGCGTTGCCGAAGACGCTCAC
CGCCAGGTTCTTCGCGCTCTCGGACCGAATGGAACGATATGGCCCGAATCTGGGCGAACCGCACACCAGGTCGATGGGCG
ACGGGTTGTATGAAATGCGCTTGAAGGGCCTGGAAGGTATCGCCCGTGTGTTTTACTGCGCGGTCGTCAATCGTCGGATT
GTCATGCTTCACTGCTTCGTGAAGAAGACCCCGAAGACGCCGCCGAAAGAGCTGGAAACTGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10550.19 Da        Isoelectric Point: 10.3379

>AT64640 WP_069749624.1 NZ_CP016443:c2494981-2494694 [Burkholderia stabilis]
MATYRELRERALADPTIRAEYERLNREEFALLDTMLAARRAAGLSQADVAERMGTKAPAITRLERALATGRHSPSIETLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT64640 NZ_CP016443:c2494981-2494694 [Burkholderia stabilis]
ATGGCAACCTATAGGGAATTGCGCGAACGCGCGCTAGCCGATCCGACGATACGCGCCGAATACGAGCGATTGAATCGCGA
GGAATTCGCGCTGCTCGATACGATGCTTGCCGCCCGTCGGGCCGCCGGTCTTTCACAAGCCGATGTTGCGGAGCGCATGG
GCACGAAGGCGCCAGCCATCACGCGGCTCGAGCGCGCGCTCGCGACGGGTCGGCACTCTCCGTCCATTGAAACGCTGCGC
AAGTATGCTGCCGCTTGCGGAAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZNQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZNQ6

References