Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 359885..360528 Replicon chromosome
Accession NZ_CP016432
Organism Prosthecochloris sp. CIB 2401 strain CIB2401

Toxin (Protein)


Gene name higB Uniprot ID A0A1B1PZU5
Locus tag Ptc2401_RS01575 Protein ID WP_068866166.1
Coordinates 360208..360528 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B1Q028
Locus tag Ptc2401_RS01570 Protein ID WP_068866165.1
Coordinates 359885..360208 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ptc2401_RS01565 355279..359742 - 4464 WP_068866164.1 translocation/assembly module TamB -
Ptc2401_RS01570 359885..360208 - 324 WP_068866165.1 helix-turn-helix domain-containing protein Antitoxin
Ptc2401_RS01575 360208..360528 - 321 WP_068866166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Ptc2401_RS01580 360591..361079 - 489 WP_068866167.1 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase -
Ptc2401_RS01585 361268..362164 + 897 WP_068866168.1 lysophospholipid acyltransferase family protein -
Ptc2401_RS01590 362556..363509 + 954 WP_068866169.1 glycosyltransferase family 2 protein -
Ptc2401_RS01595 363668..364309 + 642 WP_204208367.1 class I SAM-dependent methyltransferase -
Ptc2401_RS01600 364319..365209 + 891 WP_068866170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-95)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12448.74 Da        Isoelectric Point: 10.6501

>T64622 WP_068866166.1 NZ_CP016432:c360528-360208 [Prosthecochloris sp. CIB 2401]
MNDTIEYYHPCIEADIDKWPVSIRSNYRHISRLLVKHGPQVRMPHTKAMGDGLFEMRPKGRDGIGRAFYCYLKGKKIIVL
HAFIKKTQKTPPKELRIALNRMKEVR

Download         Length: 321 bp

>T64622 NZ_CP016432:c360528-360208 [Prosthecochloris sp. CIB 2401]
ATGAATGACACAATTGAATATTACCACCCATGCATTGAGGCGGACATTGACAAGTGGCCTGTGAGTATCAGGTCAAATTA
TCGGCATATCTCTCGACTGCTCGTAAAACACGGGCCACAAGTTAGGATGCCACACACAAAAGCCATGGGAGACGGGTTAT
TTGAGATGAGACCAAAAGGTCGAGATGGAATAGGGAGAGCCTTCTACTGTTACCTTAAAGGTAAAAAGATTATCGTTTTG
CATGCTTTTATAAAAAAGACACAAAAAACCCCGCCAAAAGAACTTAGAATTGCTCTCAACCGAATGAAGGAGGTCCGCTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12114.02 Da        Isoelectric Point: 8.8562

>AT64622 WP_068866165.1 NZ_CP016432:c360208-359885 [Prosthecochloris sp. CIB 2401]
MENLKYQPVPYDVEATIRRELKDKEFRKEFEELEPMYALISELLTARKLSGMTQEAVANKIGTTKSAISRLEGGSKHAPS
VTTLRKYAEAVGCDLVIKLEPKRKTEV

Download         Length: 324 bp

>AT64622 NZ_CP016432:c360208-359885 [Prosthecochloris sp. CIB 2401]
ATGGAGAATTTAAAATATCAGCCTGTACCATATGATGTAGAAGCTACCATCCGCAGGGAGCTTAAGGATAAAGAGTTCCG
TAAGGAGTTTGAAGAGCTTGAACCAATGTACGCTCTGATTAGTGAGCTTTTAACAGCACGCAAACTTTCCGGGATGACAC
AGGAAGCTGTTGCTAACAAAATTGGTACAACGAAGAGCGCAATCTCAAGACTTGAGGGTGGGAGCAAACATGCACCCTCT
GTAACTACGTTGAGGAAATACGCTGAAGCAGTTGGATGCGACCTCGTCATCAAACTTGAGCCAAAACGGAAAACAGAAGT
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1PZU5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1Q028

References