Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1401948..1402648 Replicon chromosome
Accession NZ_CP016431
Organism Bordetella bronchiseptica strain I328

Toxin (Protein)


Gene name mqsR Uniprot ID A0A807DZC1
Locus tag BBB44_RS06740 Protein ID WP_068925399.1
Coordinates 1401948..1402244 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag BBB44_RS06745 Protein ID WP_003809516.1
Coordinates 1402247..1402648 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB44_RS06715 1396952..1398082 - 1131 WP_068925397.1 helix-turn-helix transcriptional regulator -
BBB44_RS06720 1398330..1398872 + 543 WP_015064289.1 MOSC domain-containing protein -
BBB44_RS06725 1399048..1400112 + 1065 WP_015064288.1 fructose-bisphosphate aldolase class II -
BBB44_RS06730 1400197..1400643 - 447 WP_033464956.1 GFA family protein -
BBB44_RS06735 1400871..1401752 + 882 WP_033464953.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
BBB44_RS06740 1401948..1402244 + 297 WP_068925399.1 type II toxin-antitoxin system MqsR family toxin Toxin
BBB44_RS06745 1402247..1402648 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BBB44_RS23860 1402668..1402904 + 237 WP_003809519.1 hypothetical protein -
BBB44_RS06750 1402912..1403391 + 480 WP_003809523.1 disulfide bond formation protein B -
BBB44_RS06755 1403539..1404054 + 516 WP_033464945.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BBB44_RS06760 1404057..1405247 + 1191 WP_068925401.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BBB44_RS06765 1405266..1406303 + 1038 WP_068925403.1 threonylcarbamoyl-AMP synthase -
BBB44_RS06770 1406439..1407461 + 1023 WP_068925405.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10592.55 Da        Isoelectric Point: 8.5344

>T64619 WP_068925399.1 NZ_CP016431:1401948-1402244 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGKVRATFSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

>T64619 NZ_CP016431:1401948-1402244 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCAAGGTCCGAGCCACGTTTTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGCGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT64619 WP_003809516.1 NZ_CP016431:1402247-1402648 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT64619 NZ_CP016431:1402247-1402648 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGCGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807DZC1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References