Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2447227..2447411 Replicon chromosome
Accession NZ_CP016398
Organism Staphylococcus aureus strain FORC_040

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag FORC40_RS12640 Protein ID WP_000482650.1
Coordinates 2447304..2447411 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2447227..2447287 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC40_RS12615 2442737..2442904 - 168 WP_001792506.1 hypothetical protein -
FORC40_RS12625 2443135..2444868 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
FORC40_RS12630 2444893..2446656 - 1764 WP_001064820.1 ABC transporter ATP-binding protein/permease -
- 2447227..2447287 + 61 - - Antitoxin
FORC40_RS12640 2447304..2447411 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
FORC40_RS12645 2447545..2447931 - 387 WP_000779358.1 flippase GtxA -
FORC40_RS12650 2448189..2449331 + 1143 WP_001176863.1 glycerate kinase -
FORC40_RS12655 2449391..2450050 + 660 WP_000831298.1 membrane protein -
FORC40_RS12660 2450232..2451443 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FORC40_RS12665 2451566..2452039 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T64568 WP_000482650.1 NZ_CP016398:c2447411-2447304 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T64568 NZ_CP016398:c2447411-2447304 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT64568 NZ_CP016398:2447227-2447287 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References