64567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2421855..2422372 Replicon chromosome
Accession NZ_CP016398
Organism Staphylococcus aureus strain FORC_040

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FORC40_RS12480 Protein ID WP_000113262.1
Coordinates 2421855..2422121 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FORC40_RS12485 Protein ID WP_000584499.1
Coordinates 2422121..2422372 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC40_RS12455 2417278..2417814 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FORC40_RS12460 2418048..2418872 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FORC40_RS12465 2419089..2419271 - 183 WP_000079142.1 hypothetical protein -
FORC40_RS12470 2419358..2419825 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FORC40_RS12475 2420011..2421561 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FORC40_RS12480 2421855..2422121 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FORC40_RS12485 2422121..2422372 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC40_RS12490 2422537..2422638 - 102 Protein_2308 hypothetical protein -
FORC40_RS12495 2422645..2423244 - 600 WP_000162803.1 DsbA family protein -
FORC40_RS12500 2423263..2423625 - 363 WP_000819843.1 DUF4467 domain-containing protein -
FORC40_RS12505 2423880..2425130 + 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
FORC40_RS12510 2425227..2425958 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FORC40_RS12515 2425955..2426674 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T64567 WP_000113262.1 NZ_CP016398:c2422121-2421855 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T64567 NZ_CP016398:c2422121-2421855 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT64567 WP_000584499.1 NZ_CP016398:c2422372-2422121 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT64567 NZ_CP016398:c2422372-2422121 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References